Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Perinatal complications, environmental factors and autism spectrum disorders
Vanja Mandic-Maravic,Milica Pejovic-Milovancevic,Tatjana Pekmezovic,Marija Pljesa-Ercegovac,Marija Mitkovic-Voncina,Dusica Lecic-Tosevski +5 more
TL;DR: This review of recent studies that explored the effect of environmental, prenatal and perinatal risk factors on development of ASD points out those factors that have been proven to have the strongest association with ASD, and emphasizes a very complex interaction of individual factors that might eventually lead to manifestation of this group of disorders.
Journal ArticleDOI
Oxidative stress and mitochondrial dysfunction as key players in neurological disorders of childhood
TL;DR: The role of oxidative stress and mitochondrial dysfunction as key players in the neurodevelopmental pathophysiology are highlighted and biomarkers related to both aspects will be highlighted to demonstrate their importance in the early diagnosis of neuro developmental disorders like autism, cerebral palsy and others.
Dissertation
Understanding the genetic basis of phenotype variability in individuals with neurocognitive disorders
TL;DR: The hypothesis that phenotypic heterogeneity observed in populations with a known pathogenic variant, such as the 16p11.2 CNV as well as that associated with the ASDs in general, is due to additional genetic factors is tested.
Book ChapterDOI
Neurotoxins and Autism
TL;DR: This chapter summarizes the most important routes of exposure to environmental neurotoxins and explains how these toxins are related to the remarkable increase in the prevalence of autism through different etiological mechanisms such as oxidative stress, neuroinflammation, impaired neurochemistry and glutamate excitotoxicity.
Patent
Metabolic biomarkers of autism
Gabriela G. Cezar,Alan M. Smith +1 more
TL;DR: In this article, a method for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic patients is described.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?