Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
Journal ArticleDOI
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
TL;DR: Evidence supports the notion that mitochondrial dysfunction is associated with autism spectrum disorders, and suggests children with ASD have a spectrum of mitochondrial dysfunction of differing severity.
Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
The neurobiology of autism
TL;DR: The molecular pathways altered in autism are linked to the neurodevelopmental and clinical changes that characterize the disease, and evidence implicating oxidative stress, neuroglial activation and neuroimmunity is discussed.
Journal ArticleDOI
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
References
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Journal ArticleDOI
Lipid peroxidation and homocysteine induced toxicity
TL;DR: Even though lipid peroxidation accompanied the toxicity induced by homocysteine and homocy steine plus Cu2+, inhibition of lipid per oxidation in either case had no effect on cell viability and the significance of these results is discussed.
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Niacin and vitamin b6 in mental functioning : a review of controlled trials in humans
Jos Kleijnen,P.G. Knipschild +1 more
TL;DR: It turns out that virtually all trials show serious short-comings: in the number of participants, the presentation of baseline characteristics and outcomes, and the description of changes in concomitant treatments.
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Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress.
M. De la Fuente,Victor M. Victor +1 more
TL;DR: The data suggest that lymphocytes are important targets of endotoxins contributing to oxidative stress by septic shock, and that antioxidants can preserve the function of lymphocytes, preventing the homeostatic disturbances caused by endotoxin.
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Urinary levels of neopterin and biopterin in Autism
TL;DR: High performance liquid chromatography analyses of urinary pterins in a group of pre-school autistic children, their siblings and age-matched control children support the possible involvement of cell-mediated immunity in the aetiology of autism.
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The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice.
TL;DR: The results show that the ingestion of 0.1% doses of thiols improves, in the adult mice, several immune functions such as the chemotaxis capacity of both macrophage and lymphocytes, the phagocytosis of macrophages, the lymphoproliferative response to the mitogen, a function that is very depressed with aging.