Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Study of genotype–phenotype correlation of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in a sample of Egyptian autistic children
Rabah M. Shawky,Farida El-Baz,Tarek M. Kamal,Reham M. Elhossiny,Mona A. Ahmed,Ghada H. El Nady +5 more
TL;DR: The delayed motor and social milestones showed a statistically highly significant difference in cases of autism compared to controls, and the relation between low birth weight and occurrence of autism is highly significant.
Journal ArticleDOI
Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism.
Bruna da Silveira de Mattos,Mayara Sandrielly Pereira Soares,Luiza Spohr,Nathalia Stark Pedra,Fernanda Cardoso Teixeira,Anita Avila de Souza,Francieli Moro Stefanello,Jucimara Baldissarelli,Giovana Duzzo Gamaro,Roselia Maria Spanevello +9 more
TL;DR: It is demonstrated that quercetin has neuroprotective effects in an animal model of autism, suggesting that this natural molecule could be an important therapeutic agent for treatment of autism spectrum disorders (ASDs).
Interaction between Manganese and GSTP1 in Relation to Autism Spectrum Disorder While Controlling for Exposure to Mixture of Lead, Mercury, Arsenic, and Cadmium
TL;DR: After adjusting for the mixture of four metals, the interactive association of BMC and GSTP1 with ASD remained significant with similar magnitude of associations.
Journal ArticleDOI
The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation.
TL;DR: The relevant genomic, biochemical, and nutritional literature supports the central hypothesis that most ASD symptoms are consistent with symptoms of aldehyde toxicity, which represents a paradigm shift in thinking and has profound implications for clinical detection, treatment, and even prevention of ASD.
Autism: The Centrality of Active Pathophysiology and the Shift from Static to Chronic Dynamic Encephalopathy
TL;DR: The classical model: behavioral syndrome deriving from genetically determined static encephalopathy and research questions for a whole-body approach to ASD, which focuses on the relationship between brain and somatic/systemic features, and multi-leveled complexity in autism are described.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?