Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus.
TL;DR: It is established that maternal diabetes disrupts the regulation of both IR and IGF1R in the hippocampus of rat newborn, andsecting out the mechanisms responsible for maternal diabetes-related changes in the development of hippocampus is helping to prevent from impaired cognitive and memory functions in offspring.
Journal ArticleDOI
Evaluating mitochondrial DNA variation in autism spectrum disorders.
Athena Hadjixenofontos,Michael A. Schmidt,Patrice L. Whitehead,Ioanna Konidari,Dale J. Hedges,Harry H. Wright,Ruth K. Abramson,Ramkumar Menon,Scott M. Williams,Michael L. Cuccaro,Jonathan L. Haines,John R. Gilbert,Margaret A. Pericak-Vance,Eden R. Martin,Jacob L. McCauley +14 more
TL;DR: This work has sought to comprehensively examine the role of mitochondrial DNA (mtDNA) variation with regard to ASD risk, employing a multi‐phase approach.
Journal Article
Hyperbaric oxygen therapy in Thai autistic children.
Jessada Chungpaibulpatana,Tappana Sumpatanarax,Noppol Thadakul,Chansin Chantharatreerat,Maytinee Konkaew,Methira Aroonlimsawas +5 more
TL;DR: Whether Hyperbaric Oxygen Therapy is safe to use in children with autism, and has a statistically significant effect on autistic symptoms is determined to determine.
Journal ArticleDOI
Epigenetics and Autism
Tafari Mbadiwe,Richard M. Millis +1 more
TL;DR: This review identifies mechanisms for altering DNA-histone interactions of cell chromatin to upregulate or downregulate gene expression that could serve as epigenetic targets for therapeutic interventions in autism.
Journal ArticleDOI
Autistic disorder and phospholipids: A review.
TL;DR: More research is needed to ascertain whether breastfeeding, and specifically, the administration of colostrum or an adequate substitute can play a preventative role by supplying the neonate with essential fatty acids (EFAs) at a critical juncture in their development.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?