Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
Stepan Melnyk,Stepan Melnyk,George J. Fuchs,George J. Fuchs,Eldon G. Schulz,Eldon G. Schulz,Maya Lopez,Maya Lopez,Stephen G. Kahler,Stephen G. Kahler,Jill J. Fussell,Jill J. Fussell,Jayne Bellando,Jayne Bellando,Oleksandra Pavliv,Oleksandra Pavliv,Shannon Rose,Shannon Rose,Lisa Seidel,Lisa Seidel,David W. Gaylor,S. Jill James,S. Jill James +22 more
TL;DR: The data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression, and suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism.
Journal ArticleDOI
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism
S J James,S Melnyk,George J. Fuchs,Reid T,Stefanie Jernigan,Oleksandra Pavliv,Amanda Hubanks,David W. Gaylor +7 more
TL;DR: The significant improvements observed in transmethylation metabolites and glutathione redox status after treatment suggest that targeted nutritional intervention with methylcobalamin and folinic acid may be of clinical benefit in some children who have autism.
Journal ArticleDOI
Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders.
TL;DR: The hypothesis that ASDs are produced by pre- or post-natal alterations in intestinal microbiota in sensitive sub-populations is discussed, which may have major implications in ASD cause, diagnosis, prevention, and treatment.
Journal ArticleDOI
Cerebral folate receptor autoantibodies in autism spectrum disorder
TL;DR: It is suggested that FRAs may be important in ASD and that FRA-positive children with ASD may benefit from leucovorin calcium treatment, and additional studies of folate receptor autoimmunity and leucovsky calcium treatment in children with ASDs are warranted.
Journal ArticleDOI
Dysregulated relationship of inflammation and oxidative stress in major depression
B.J. Rawdin,Synthia H. Mellon,Firdaus S. Dhabhar,Elissa S. Epel,Eli Puterman,Y. Su,Heather M. Burke,Victor I. Reus,Rebecca Rosser,Steven P. Hamilton,J.C. Nelson,Owen M. Wolkowitz +11 more
TL;DR: The data suggest oxidative stress and inflammatory processes are positively associated in untreated MDD, consistent with the hypothesis that the homeostatic buffering mechanisms regulating oxidation and inflammation in healthy individuals become dysregulated in untreatedMDD, and may be improved with antidepressant treatment.
References
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Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
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