Journal ArticleDOI
Propionate as a health-promoting microbial metabolite in the human gut.
TLDR
The present review discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to producepropionate and evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionates.Abstract:
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.read more
Citations
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Journal ArticleDOI
The Chelating Mineral on Organic Acid Salts Modulates the Dynamics and Richness of the Intestinal Microbiota of a Silver Catfish Rhamdia quelen
Scheila Anelise Pereira,Gabriel Fernandes Alves Jesus,Gabriella do Vale Pereira,Bruno Corrêa da Silva,Lúvia Souza de Sá,Maurício Laterça Martins,José Luiz Pedreira Mouriño +6 more
TL;DR: The HTS showed that the supplementation of the propionic acid chelated to the mineral calcium or sodium in the different concentrations increased the operational taxonomic units and richness in comparison to control group.
Dissertation
Can fermentation-derived propionic acid spare glucogenic amino acids in domestic cats?
TL;DR: Information is presented at international conferences on the effects of guar gum on in vivo fermentation kinetics and end product profile in cats, as well as in vitro evaluation of fibre and protein fermentation substrates in cats.
Journal ArticleDOI
The Effect of Amino Acids on Production of SCFA and bCFA by Members of the Porcine Colonic Microbiota
Pieter Van den Abbeele,Jonas Ghyselinck,Massimo Marzorati,Anna-Maria Koch,William Lambert,Joris Michiels,Tristan Chalvon-Demersay +6 more
TL;DR: High-quality 16S rRNA gene profiling with flow cytometry demonstrated that specific microbial taxa were involved in the fermentation of each of the amino acids resulting in the production of specific metabolites, confirming the prebiotic potential of specific functional amino acids.
Book ChapterDOI
Short-Chain Fatty Acids
TL;DR: Short-chain fatty acids are formed in the colon as a result of microbial fermentation of undigested bioactive carbohydrates, including prebiotics and dietary fiber, and their significant role in orchestrating colon carcinogenesis is of current interest among researchers.
References
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Journal ArticleDOI
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
TL;DR: By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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