Journal ArticleDOI
Propionate as a health-promoting microbial metabolite in the human gut.
TLDR
The present review discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to producepropionate and evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionates.Abstract:
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.read more
Citations
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Journal ArticleDOI
An updated genome-scale metabolic network reconstruction of Pseudomonas aeruginosa PA14 to characterize mucin-driven shifts in bacterial metabolism.
TL;DR: In this article, the genome-scale metabolic network reconstruction (GENRE) of Pseudomonas aeruginosa PA14 was updated through metabolic coverage expansion, format update, extensive annotation addition, and literature-based curation to produce iPau21.
Journal ArticleDOI
Prebiotic-Like Effects of SweetPearl® Maltitol through Changes in Caecal and Fecal Parameters
Clémentine Thabuis,Anne-Charlotte Herbomez,Fabrice Desailly,Florence Ringard,Daniel Wils,Laetitia Guérin-Deremaux +5 more
TL;DR: Maltitol could induce prebiotic-like effects andFaecal parameters were influenced by the dietary supplementation with maltitol: the amount of dry matter in feces decreased and alpha-glucosidase activity increased.
Journal ArticleDOI
In vitro–in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli
Cindy Duysburgh,Pieter Van den Abbeele,Alison Kamil,Lisa Fleige,Peter John D. De Chavez,YiFang Chu,Wiley Barton,Orla O'Sullivan,Paul D. Cotter,Karina Quilter,Susan A. Joyce,Mike Murphy,Gillian DunnGalvin,Timothy G. Dinan,Massimo Marzorati +14 more
TL;DR: The prebiotic activity of a commercially available oat product and a novel oat ingredient, at similar β-glucan loads, was tested using a validated in vitro gut model (M-SHIME®) as mentioned in this paper.
Journal ArticleDOI
Electroacupuncture interventions alleviates myocardial ischemia reperfusion injury through regulating gut microbiota in rats.
Hua Bai,Ren-Jun Gu,Li-Yao Chen,Yi Qian,Mei-Ling Yu,Sen-Lei Xu,Xue-Feng Xia,Yu-Chen Liu,Hong-Ru Zhang,Yi-Huang Gu,Sheng-Feng Lu +10 more
TL;DR: In this article, the authors demonstrate the relationship between gut microbiota and cardioprotection of electroacupuncture on myocardial ischemia reperfusion injury (MIRI) in male Sprague Dawley rats, which then received 7 days of EA intervention.
Journal ArticleDOI
Perinatal Propionate Supplementation Protects Adult Male Offspring from Maternal Chronic Kidney Disease-Induced Hypertension
TL;DR: In this paper , a perinatal propionate supplement was used to prevent offspring hypertension induced by maternal chronic kidney disease (CKD) during pregnancy and lactation. But, the effect of the supplement on the early-life disturbance of gut microbiota has an impact on adult disease in later life.
References
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Journal ArticleDOI
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
TL;DR: By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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