Journal ArticleDOI
Propionate as a health-promoting microbial metabolite in the human gut.
TLDR
The present review discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to producepropionate and evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionates.Abstract:
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.read more
Citations
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Journal ArticleDOI
Investigating the effects of conventional and unconventional edible parts of red beet (Beta vulgaris L.) on target bacterial groups and metabolic activity of human colonic microbiota to produce novel and sustainable prebiotic ingredients
TL;DR: In this article , the effects of freeze-dried red beet root (FDBR) and FDBSL on target bacterial groups and metabolic activity of human colonic microbiota in vitro were investigated.
Book ChapterDOI
Probiotics as Next Generation Strategy for Cancer Therapy
TL;DR: Probiotics are the substances used for improving health status by improving the fitness of the intestine and overall host health as discussed by the authors, which can maintain sustainable physicochemical conditions by reducing the number of harmful bacteria and in turn decreasing the level of enzymes like glucuronidase and nitroreductase.
Journal ArticleDOI
Characterization and fermentability of sucrose thermolysis oligosaccharides caramel by human intestinal microbiota
TL;DR: Sucrose thermolysis oligosaccharides caramel (STOC) was prepared by thermal treatment (160°C) under vacuum of acidified sucrose using citric acid as caramelization catalyst as mentioned in this paper.
Journal ArticleDOI
Association of Serum Vitamin B12 and Circulating Methylmalonic Acid Levels with All-Cause and Cardiovascular Disease Mortality among Individuals with Chronic Kidney Disease
TL;DR: In this article , a prospective cohort study included 2589 individuals with chronic kidney disease (CKD) who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004, and from 2011 to 2014, respectively.
References
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Journal ArticleDOI
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
TL;DR: By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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