Journal ArticleDOI
Propionate as a health-promoting microbial metabolite in the human gut.
TLDR
The present review discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to producepropionate and evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionates.Abstract:
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.read more
Citations
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Journal ArticleDOI
Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients
Hoda M. Eid,Hoda M. Eid,Michelle L. Wright,N. V. Anil Kumar,Abdel Qawasmeh,Sherif T. S. Hassan,Andrei Mocan,Andrei Mocan,Seyed Mohammad Nabavi,Luca Rastrelli,Atanas G. Atanasov,Atanas G. Atanasov,Atanas G. Atanasov,Pierre S. Haddad,Pierre S. Haddad +14 more
TL;DR: Light is shed on the composition of gut microbes, their health importance and how they can contribute to diseases as well as their modulation by polyphenols and polysaccharides to control obesity and diabetes.
Journal ArticleDOI
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy.
TL;DR: Targeting the SCFA transporters to regulate lactate generation and export of BT, as well as applying SCFAs or gut microbiota and natural compounds for chemoprevention may be clinically useful for CRCs treatment.
Journal ArticleDOI
Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.
Mikayla A. Borton,Anice Sabag-Daigle,Jikang Wu,Lindsey M. Solden,Bridget S. O’Banion,Rebecca A. Daly,Richard A. Wolfe,Juan F. González,Vicki H. Wysocki,Brian M. M. Ahmer,Kelly C. Wrighton +10 more
TL;DR: The results show that enteropathogenic infection and intestinal inflammation are interrelated factors modulating gut homeostasis and may prove informative with regard to prophylactic or therapeutic strategies to prevent disruption of microbial communities, or promote their restoration.
Journal ArticleDOI
Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life
Naoki Tsukuda,Kana Yahagi,Taeko Hara,Yohei Watanabe,Hoshitaka Matsumoto,Hiroshi Mori,Koichi Higashi,Hirokazu Tsuji,Satoshi Matsumoto,Ken Kurokawa,Takahiro Matsuki +10 more
TL;DR: In this paper, the authors investigated dense longitudinally collected faecal samples from 12 subjects during the first 2 years to identify early life short-chain fatty acids (SCFAs) patterns and their relationships with the microbiota.
Journal ArticleDOI
Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine.
Artur Rogowski,Jonathon A. Briggs,Jennifer C. Mortimer,Theodora Tryfona,Nicolas Terrapon,Elisabeth C. Lowe,Arnaud Baslé,Carl Morland,Alison M. Day,Hongjun Zheng,Theresa E. Rogers,Paul M. Thompson,Alastair R. Hawkins,Madhav P. Yadav,Bernard Henrissat,Eric C. Martens,Paul Dupree,Harry J. Gilbert,David N. Bolam +18 more
TL;DR: This work was supported in part by a grant to H.J.G., B.H. and N.T. (European Union's Seventh Framework Program (FP/2007/2013)/European Research Council (ERC) Grant Agreement 322820).
References
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Journal ArticleDOI
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
TL;DR: By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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