Journal ArticleDOI
Propionate as a health-promoting microbial metabolite in the human gut.
TLDR
The present review discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to producepropionate and evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionates.Abstract:
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.read more
Citations
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Journal ArticleDOI
The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD.
Shuhui Liu,Zhangshan Gao,Wa He,Yuting Wu,Ji-Wen Liu,Shuo Zhang,Liping Yan,Shengyong Mao,Xizhi Shi,Wentao Fan,Suquan Song +10 more
TL;DR: Wang et al. as mentioned in this paper found that bromoacetic acid (BAA), a typical kind of environmental toxin, increased triglycerides and total cholesterol levels as well as induced obvious hepatic steatosis and inflammation.
Journal ArticleDOI
Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities
Ghanyah H. Al-Qadami,Kate R. Secombe,Courtney B. Subramaniam,Hannah R. Wardill,Joanne M. Bowen +4 more
TL;DR: The importance of SCFAs and their implications for cancer treatment response and toxicities are discussed.
Development of gut microbiota in pigs and the effect of diet, antibiotics and other environmental factors
TL;DR: The notion that the early phase of life is critical for intestinal immune development, also under regular production circumstances was reinforced, and the effect of management procedures on top of the use of an antibiotic was limited.
Journal ArticleDOI
The fungal community and its interaction with the concentration of short‐chain fatty acids in the caecum and colon of weaned piglets
Jiayan Li,Yuheng Luo,Daiwen Chen,Bing Yu,Jun He,Zhiqing Huang,Xiangbing Mao,Ping Zheng,Jie Yu,Junqiu Luo,Gang Tian,Hui Yan,Quyuan Wang,Huifen Wang +13 more
TL;DR: A probable interaction between the fungal composition and the bacterial degradation of protein and complex carbohydrates in the diet is illuminated and would be helpful to enhance the understanding of fungi in swine gut.
Journal ArticleDOI
Bacterial Microcompartment-Dependent 1,2-Propanediol Utilization of Propionibacterium freudenreichii.
TL;DR: In this paper, it was shown that 1,2-propanediol induced the formation of BMCs, which were visualized by transmission electron microscopy and resembled BMCs found in other bacteria.
References
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Journal ArticleDOI
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
TL;DR: By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
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