Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Radix Glycyrrhizae extract and licochalcone a exert an anti-inflammatory action by direct suppression of toll like receptor 4.
Min Cai,You-cai Xu,Bo Deng,Jun Chen,Ting Chen,Ke Zeng,Si Chen,Sui-hui Deng,Zhang-Bin Tan,Wen-jun Ding,Shuangwei Zhang,Bin Liu,Jingzhi Zhang +12 more
TL;DR: In this article , the authors investigated the involvement of TLR4 in the anti-inflammatory mechanism of Radix Glycyrrhizae (GL) extract and its active constituent on acute lung injury (ALI).
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Inhibition of A1 Astrocytes and Activation of A2 Astrocytes for the Treatment of Spinal Cord Injury
Jingxuan Wang,C. Cheng,Zhong Hong Liu,Yan Lin,Lingling Yang,Zijun Zhang,Xiaoduan Sun,Meiling Zhou,Pei Jing,Zhirong Zhang +9 more
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Catalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells
TL;DR: In this paper , the authors explored whether catalpol protects against angiotensin II (Ang II)-triggered blood-brain barrier (BBB) leakage, and showed that catalpol dose-dependently reversed these changes at 50-500μM.
Journal ArticleDOI
White Matter Damage in Alzheimer’s Disease: Contribution of Oligodendrocytes
TL;DR: A review comprehensively summarize the results on WM abnormalities in AD and explores the relationship between OL progenitor cells and the pathogenesis of AD.
Journal ArticleDOI
Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells
Ana Bruna de Araújo,F. V. C. S. Azul,Francisca Raysse Mesquita Silva,Talysson Silva de Almeida,João Victor Souza Oliveira,Antônia Torres Ávila Pimenta,Antonio Marcos Esmeraldo Bezerra,Nuno J Machado,Luzia Kalyne Almeida Moreira Leal +8 more
TL;DR: DEAC, CM, and AMB exerted anti-inflammatory activity in LPS-activated microglial cells as observed by the reduction in the production of inflammatory mediators and the expression of iNOS.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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