Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
Citations
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An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain
TL;DR: Successful therapies for reducing neuroinflammation will likely involve an integrated approach combining drug therapy with nonpharmacologic interventions.
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Antioxidant Therapies for Neuroprotection-A Review.
Raluca Ioana Teleanu,Cristina Chircov,Alexandru Mihai Grumezescu,Adrian Volceanov,Daniel Mihai Teleanu +4 more
TL;DR: An overview of the oxidative stress and antioxidant defense mechanisms is provided and the most recent studies on antioxidant therapies for neuroprotection are presented.
Journal ArticleDOI
Myricetin attenuated LPS induced cardiac injury in vivo and in vitro.
TL;DR: Myricetin could attenuate the LPS induced cardiac inflammation injury in vivo and in vitro, and may be a potential therapy or adjuvant therapy for SIMD.
Journal ArticleDOI
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Chuan Qin,Sheng Yang,Yunjie Chu,Hang-xiang Zhang,Xiaoyi Pang,Lian Chen,Luoqi Zhou,Man Chen,Dai-Shi Tian,Wei Wang +9 more
TL;DR: In this paper , the authors describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate in, and summarize the therapeutic approaches targeted various pathophysiology.
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Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.
TL;DR: Interestingly, micro-computed tomography data suggested that curcumin treatment could promote disc height recovery following disc herniation, and provided pre-clinical evidence for expediting this natural, non-toxic pleiotropic agent to become a new and safe clinical treatment of radiculopathy.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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