Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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TLR4-Pathway-Associated Biomarkers in Subarachnoid Hemorrhage (SAH): Potential Targets for Future Anti-Inflammatory Therapies
Rebecca Heinz,Ulf C. Schneider +1 more
TL;DR: This review focuses on the activity of the TLR4 pathway and its contributors, which can act as biomarkers of neuroinflammation or even offer potential new treatment targets for secondary neuronal cell death after SAH.
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Preparation, characterization and immunomodulatory effects of unsaturated sulfated oligoguluronic acid.
Decheng Bi,Jinfeng Huang,Jue Cao,Lijun Yao,Wushuang Guo,Zhenqing Zhang,Yan Wu,Hong Xu,Zhang-li Hu,Xu Xu +9 more
TL;DR: In this article , a sulfated saccharide (SOGA) was synthesized by sulfating polyguluronic acid (PG) derived unsaturated oligogulurony acid (OGA), which is a type of polysaccharide found in edible brown seaweeds.
Journal ArticleDOI
Acertannin attenuates LPS-induced inflammation by interrupting the binding of LPS to the TLR4/MD2 complex and activating Nrf2-mediated HO-1 activation
TL;DR: In this paper , the anti-inflammatory effects of Acertannin and its signaling pathway were evaluated at the molecular level, where the expression of proinflammatory markers was measured in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
Journal ArticleDOI
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways
Journal ArticleDOI
Berberine-Loaded M2 Macrophage-Derived Exosomes for Spinal Cord Injury Therapy
TL;DR: Designing M2-type primary peritoneal macrophages exosomes (Exos) as a drug carrier for berberine (Ber), which can be efficiently targeted to deliver drugs to the injured spinal cord due to the natural advantage of Exos across the BBB, indicated that Exos-Ber is a potential agent for SCI therapy.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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