Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
Citations
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Anti-inflammatory effects of flavonoids in neurodegenerative disorders
TL;DR: The present work reviews the role of inflammation in neurodegenerative diseases, highlighting the potential therapeutic effects of flavonoids as a promising approach to develop innovative neuroprotective strategy.
Journal ArticleDOI
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
TL;DR: The role of the TLR4 signaling pathway between inflammatory response and cancer progression is described and bioactive phytochemicals with potential anti-inflammation and chemoprevention by inhibiting TLR activation are introduced.
Journal ArticleDOI
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage.
Huimin Zhu,Zhiqiang Wang,Jixu Yu,Xiuli Yang,Feng He,Zhenchuan Liu,Fengyuan Che,Xuemei Chen,Honglei Ren,Michael Hong,Jian Wang +10 more
TL;DR: A review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.
Journal ArticleDOI
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Jun Zheng,Rong Fan,Huiqiong Wu,Huiqiong Wu,Honghui Yao,Yujie Yan,Jiamiao Liu,Lu Ran,Zhifang Sun,Lunzhao Yi,Li Dang,Pingping Gan,Piao Zheng,Tilong Yang,Yi Zhang,Tao Tang,Yang Wang +16 more
TL;DR: Rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions, shows excellent stability, sustained release and reversible stimuli-responses and is applied as stable controlled release agents for neuro-inflammatory therapy.
Journal ArticleDOI
AMPK: Potential Therapeutic Target for Ischemic Stroke.
TL;DR: The basic structure, upstream regulators, and biological roles of AMPK are introduced and the relationship between AMPK and the neurovascular unit (NVU) is analyzed, followed by ethical issues, potential directions, and further prospects of AM PK.
References
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A systematic review of Iranian medicinal plants useful in diabetes mellitus
TL;DR: It is indicated that some of the Iranian medicinal plants found effective in the management of diabetes improve blood hyperglycemia in humans somewhat more effectively than standard chemical drugs used in diabetes.
Journal ArticleDOI
The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease
TL;DR: This review criticizes the potential of commonly used polyphenols including apple polyphenol, bilberry anthocyanin, curcumin, epigallocatechin-3-gallate (EGCG) and green tea poly phenols specifically in IBD with an emphasis on cellular mechanisms and pharmaceutical aspects.
Journal ArticleDOI
Neural immunity: Friend or foe?
TL;DR: The articles compiled in this special edition of Journal of NeuroVirology target a developing field of investigation seeking to uncover how the immune system affects both the pathogenic process and protection against the ravages of neurodegenerative processes.
Journal ArticleDOI
Epigallocatechin gallate and mitochondria—A story of life and death
Marcos Roberto de Oliveira,Seyed Fazel Nabavi,Maria Daglia,Luca Rastrelli,Seyed Mohammad Nabavi +4 more
TL;DR: This review evaluates recent evidence on the ability of EGCG to exert critical influence on mitochondrial functions impacting mitochondrial biogenesis, bioenergetic control, alteration of the cell cycle, and mitochondria-related apoptosis.
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Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca2+]i, NF-κB Trafficking and Transcription
Nazira El-Hage,Annadora J. Bruce-Keller,Tatiana Yakovleva,Igor Bazov,Georgy Bakalkin,Pamela E. Knapp,Kurt F. Hauser +6 more
TL;DR: Results demonstrate that exposure to Tat±morphine is sufficient to activate NF-κB and cytokine production, and the release of MCP-1 and IL-6 by Tat± morphine are highly Ca2+-dependent, while TNF-α appears to be less affected by the changes in [Ca2+]i.
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