Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
Citations
More filters
Journal ArticleDOI
Anti-inflammatory effects of flavonoids in neurodegenerative disorders
TL;DR: The present work reviews the role of inflammation in neurodegenerative diseases, highlighting the potential therapeutic effects of flavonoids as a promising approach to develop innovative neuroprotective strategy.
Journal ArticleDOI
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
TL;DR: The role of the TLR4 signaling pathway between inflammatory response and cancer progression is described and bioactive phytochemicals with potential anti-inflammation and chemoprevention by inhibiting TLR activation are introduced.
Journal ArticleDOI
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage.
Huimin Zhu,Zhiqiang Wang,Jixu Yu,Xiuli Yang,Feng He,Zhenchuan Liu,Fengyuan Che,Xuemei Chen,Honglei Ren,Michael Hong,Jian Wang +10 more
TL;DR: A review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.
Journal ArticleDOI
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Jun Zheng,Rong Fan,Huiqiong Wu,Huiqiong Wu,Honghui Yao,Yujie Yan,Jiamiao Liu,Lu Ran,Zhifang Sun,Lunzhao Yi,Li Dang,Pingping Gan,Piao Zheng,Tilong Yang,Yi Zhang,Tao Tang,Yang Wang +16 more
TL;DR: Rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions, shows excellent stability, sustained release and reversible stimuli-responses and is applied as stable controlled release agents for neuro-inflammatory therapy.
Journal ArticleDOI
AMPK: Potential Therapeutic Target for Ischemic Stroke.
TL;DR: The basic structure, upstream regulators, and biological roles of AMPK are introduced and the relationship between AMPK and the neurovascular unit (NVU) is analyzed, followed by ethical issues, potential directions, and further prospects of AM PK.
References
More filters
Journal ArticleDOI
Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke
Javier R. Caso,Jesús M. Pradillo,Olivia Hurtado,Juan C. Leza,María A. Moro,Ignacio Lizasoain +5 more
TL;DR: The results indicate that TLR4 is involved in the inflammatory response after subacute stress and its exacerbating effect on stroke, which implicate the effects of innate immunity on inflammation and damage in the brain after stroke.
Journal ArticleDOI
A systematic review of anti-obesity medicinal plants - an update
TL;DR: In conclusion, Nigella Sativa, Camellia Synensis, Green Tea, and Black Chinese Tea seem to have satisfactory anti-obesity effects, and the effect size of these medicinal plants is a critical point that should be considered for interpretation.
Journal ArticleDOI
Adenosine and cAMP are potent inhibitors of the NF‐κB pathway downstream of immunoreceptors
Susanna Minguet,Michael Huber,Lisa Rosenkranz,Wolfgang W. A. Schamel,Michael Reth,Tilman Brummer +5 more
TL;DR: It is demonstrated that stimuli known to enhance 3′,5′‐cyclic adenosine monophosphate (cAMP) are capable of selectively suppressing the activation both of NF‐κB downstream of the BCR and Toll‐like receptor 4 in splenic B lymphocytes and of the high‐affinity receptor for IgE in BM‐derived mast cells.
Journal ArticleDOI
Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway.
Iciar Gárate,Borja García-Bueno,José L. M. Madrigal,Javier R. Caso,Luis Alou,Marisa L. Gomez-Lus,Juan Antonio Mico,Juan Antonio Mico,Juan C. Leza +8 more
TL;DR: A bifunctional role of TLR-4 signaling pathway after stress exposure is suggested by triggering neuroinflammation at PFC level and regulating gut barrier function/permeability and regulating antibiotic decontamination in stress-related pathologies such as depression.
Journal ArticleDOI
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.
TL;DR: The idea that one of the fundamental molecular mechanisms underlying the pathogenesis of cell death in AD, PD, and possibly some other protein conformational diseases, could be the direct production of ROS during formation of the abnormal protein aggregates is supported.
Related Papers (5)
LPS/TLR4 signal transduction pathway
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more