Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Dual roles of anesthetics in postoperative cognitive dysfunction: Regulation of microglial activation through inflammatory signaling pathways
Mengxue Zhang,Yiqing Yin +1 more
TL;DR: In this paper , a review of the mechanisms by which commonly used anesthetics regulate microglial activation via inflammatory signaling pathways, showing both anti-and pro-inflammatory properties of anesthetic, and indicating how perioperative administration of ananesthetic might either relieve or worsen postoperative cognitive dysfunction.
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The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids.
Leila Kooshki,Seyede Nazanin Zarneshan,Sajad Fakhri,Seyed Zachariah Moradi,Javier Echeverría +4 more
TL;DR: A systematic and comprehensive review was performed to highlight the modulatory roles of polyphenols and alkaloids on the JAK/STAT and IRS/PI3K signaling pathways in NDDs, according to the PRISMA guideline, using scholarly electronic databases, including Scopus, PubMed, ScienceDirect, and associated reference lists as mentioned in this paper .
Journal ArticleDOI
Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Jing Wang,Samiullah Khan,Panxuan Cao,Xi Chen,Feng Wang,Di Zou,Honghui Li,Heng Zhao,Kaixiang Xu,Deling Jiao,Chang-qin Yang,Feiyan Zhu,Yaxuan Zhang,Yanhua Su,Wenmin Cheng,Baoyu Jia,Yubo Qing,Muhammad Ameen Jamal,Hong-Ye Zhao,Hong Wei +19 more
TL;DR: PIK3C3 overexpression promoted autophagy in the liver and associated molecular mechanisms related to the activation of ULK1, AMBR1, DRAM1, and MTOR, causing liver damage in pigs, may provide a new experimental animal resource for liver diseases.
Journal ArticleDOI
Downregulation of miR-210 Promoted Apoptosis of Hippocampal Neurons by Negatively Regulating the TLR4/NF-кB1 Signaling Pathway in a Rat Model of Status Epilepticus
TL;DR: In this paper , the expression of microRNA-210 (miR-210), TLR4, NF-κB1 and caspase-3 were assessed by quantitative polymerase chain reaction and Western blotting.
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Evidence-based use of sea buckthorn fresh juice for patients with traumatic brain injury. a pilot study
TL;DR: The clinical results have shown beneficial effects of sea buckthorn fresh juice (given together with specific medication) in the management of patients with traumatic brain injury.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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