Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
Citations
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Anti-inflammatory effects of flavonoids in neurodegenerative disorders
TL;DR: The present work reviews the role of inflammation in neurodegenerative diseases, highlighting the potential therapeutic effects of flavonoids as a promising approach to develop innovative neuroprotective strategy.
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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
TL;DR: The role of the TLR4 signaling pathway between inflammatory response and cancer progression is described and bioactive phytochemicals with potential anti-inflammation and chemoprevention by inhibiting TLR activation are introduced.
Journal ArticleDOI
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage.
Huimin Zhu,Zhiqiang Wang,Jixu Yu,Xiuli Yang,Feng He,Zhenchuan Liu,Fengyuan Che,Xuemei Chen,Honglei Ren,Michael Hong,Jian Wang +10 more
TL;DR: A review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.
Journal ArticleDOI
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Jun Zheng,Rong Fan,Huiqiong Wu,Huiqiong Wu,Honghui Yao,Yujie Yan,Jiamiao Liu,Lu Ran,Zhifang Sun,Lunzhao Yi,Li Dang,Pingping Gan,Piao Zheng,Tilong Yang,Yi Zhang,Tao Tang,Yang Wang +16 more
TL;DR: Rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions, shows excellent stability, sustained release and reversible stimuli-responses and is applied as stable controlled release agents for neuro-inflammatory therapy.
Journal ArticleDOI
AMPK: Potential Therapeutic Target for Ischemic Stroke.
TL;DR: The basic structure, upstream regulators, and biological roles of AMPK are introduced and the relationship between AMPK and the neurovascular unit (NVU) is analyzed, followed by ethical issues, potential directions, and further prospects of AM PK.
References
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Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression.
Brian E. Leonard,Michael Maes +1 more
TL;DR: It is concluded that depression may be the consequence of a complex interplay between CMI activation and inflammation and their sequels/concomitants which all together cause neuroprogression that further shapes the depression phenotype.
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Inhibiting NF-κB activation by small molecules as a therapeutic strategy
TL;DR: Only small molecules that suppress NF-κB activation are described, and the mechanism by which they block this pathway is described.
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Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?
TL;DR: The consequences of gain versus loss of function with an emphasis on microglia as sensors and effectors of immune function in the brain are explored, and the potential role of the peripheral environment in neurodegenerative diseases is discussed.
Journal ArticleDOI
Neuroinflammatory processes in Parkinson's disease.
Stéphane Hunot,E. C. Hirsch +1 more
TL;DR: It is proposed that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process.
Journal ArticleDOI
Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells
Ying Yang,Shuping Li,Qiao Yang,Yu Shi,Min Zheng,Yanning Liu,Feng Chen,Guangzhong Song,Hangdi Xu,Tian-hong Wan,Jiliang He,Zhi Chen +11 more
TL;DR: Res can block the inflammatory effects induced by LPS in RAW264.7 cells and may also influence TLR4 expression in the HMGB1-TLR4 signaling pathway.
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