Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer's Disease Therapy.
Huaqing Zhang,Wenxin Jiang,Yuanpei Zhao,Tingting Song,Yilong Xi,Guochen Han,Yi Jin,Mingjie Song,Kaiwen Bai,Jianping Zhou,Yang Ding +10 more
TL;DR: This study exploits a native high-density lipoprotein (HDL)-inspired nanoscavenger that combines the trinity of phosphatidic acid-functionalized HDL (pHDL), curcumin (Cur), and β-site APP cleavage enzyme 1 targeted siRNA (siBACE1) to modulate microglial dysfunction to highlight the double-edged sword role of microglia and provide a promising tactic for modulating microglian dysfunction in AD treatment.
Journal ArticleDOI
The role of inflammatory mediators in epilepsy: Focus on developmental and epileptic encephalopathies and therapeutic implications.
Alessandro Orsini,Thomas Foiadelli,Giorgio Costagliola,Alexandre Michev,Rita Consolini,Federica Vinci,Diego Peroni,Pasquale Striano,Salvatore Savasta +8 more
TL;DR: In this paper, the role of innate immunity (that includes cytokines and chemokines) has been extensively investigated either in animal models of epilepsy and in clinical settings and there has been an increasing interest in the potential involvement of neuroinflammation in the pathogenesis of epilepsy.
Journal ArticleDOI
Rea regulates microglial polarization and attenuates neuronal apoptosis via inhibition of the NF-κB and MAPK signalings for spinal cord injury repair.
TL;DR: A bioactive herbal extract isolated from Rehmanniae radix with low toxicity and neuroprotection effects was used to treat spinal cord injury (SCI) as mentioned in this paper, which inhibited the release of pro-inflammatory mediators from microglial cells, and promoted M2 polarization.
Journal ArticleDOI
Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats.
Yinan Chen,Huan-Huan Sha,Yiwei Wang,Qin Zhou,Piplu Bhuiyan,Nana Li,Yanning Qian,Hongquan Dong +7 more
TL;DR: It is concluded that histamine 2/3 receptors ameliorate PND by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway.
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lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis.
TL;DR: Wang et al. as discussed by the authors investigated the role of long non-coding RNAs (lncRNAs) in mediating neuropathic pain (NP) in CCI rats.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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