Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
Citations
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Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion.
TL;DR: The results showed that melatonin might relieve neuroinflammation and cognitive dysfunction caused by intestinal I/R, which could be, at least partially, related to the inhibition of the TLR4/Myd88 signaling in microglia.
Journal ArticleDOI
Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling
Yunhao Wu,Yuwei Wang,Shuaishuai Gong,Jiahui Tang,Jia-zhi Zhang,Fang Li,Boyang Yu,Yuanyuan Zhang,Junping Kou +8 more
TL;DR: The results indicate that RUS plays a protective role against LPS-induced endothelial cell apoptosis via regulating TLR4 signaling, and may be a promising agent in the management of ALI.
Journal ArticleDOI
Polyphenolic Sunscreens for Photoprotection
TL;DR: Polyphenols are a class of compounds widely existing in living species ranging from plants, fungi, bacteria to animals, and possess various interesting functions such as anti-inflammatory, immunomodulatory, anti-oxidative and anti-ultraviolet functions.
Journal ArticleDOI
Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice.
Yanhe Wang,Zhiyuan Yin,Lixiong Gao,Dayu Sun,Xisu Hu,Langyue Xue,Jiaman Dai,Yuxiao Zeng,Siyu Chen,Boju Pan,Min Chen,Jing Xie,Haiwei Xu +12 more
TL;DR: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice, suggesting it may be an effective treatment for neurodegenerative disorders such as RP.
Journal ArticleDOI
Apple polyphenols modulates the antioxidant defense response and attenuates inflammatory response concurrent with hepatoprotective effect on grass carp (Ctenopharyngodon idellus) fed low fish meal diet
Gang Yang,Ruihe Yu,Shiyu Geng,Liufeng Xiong,Quangen Yan,Vikas Kumar,Chungen Wen,Mo Peng,Mo Peng +8 more
TL;DR: Results of the study showed that highest supplementation of AP exhibited lower growth of fish compared to other groups, and dietary inclusion ofAP exhibited hepatoprotective effects via decreasing the activities of serum alanine aminotransferase, aspartate aminotsferase and γ-glutamyl transaminase.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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