Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Dynamic Changes in Toll-Like Receptor 4 in Human Perihematoma Tissue after Intracerebral Hemorrhage.
TL;DR: The results indicate that the optimal window for antiinflammation and antiapoptosis treatment is within 6 hours after ICH, and the TLR4-mediated MyD88-dependent pathway plays a significant role in the mechanism of tissue injury after I CH in human tissues.
Journal ArticleDOI
Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome
Chao Wu,Yanqin Bian,Bingjie Lu,Dan Wang,Nisma Lena Bahaji Azami,Gang Wei,Fengyu Ma,Mingyu Sun +7 more
TL;DR: In this article , the authors explored the efficacy and mechanism of rhubarb free anthraquinones (RFAs) in treating NAFLD by inhibiting NLRP3 inflammasome.
Journal ArticleDOI
Methylated Metabolites of Chicoric Acid Ameliorate Hydrogen Peroxide (H2O2)-Induced Oxidative Stress in HepG2 Cells.
Xiaowen Chang,Shan Dong,Wenliang Bai,Yan Di,Ruijuan Gu,Fuguo Liu,Fuguo Liu,Beita Zhao,Yutang Wang,Xuebo Liu +9 more
TL;DR: In this paper, the major methylated metabolites of CA were isolated from an in vitro co-incubation system, and their structures were elucidated, and the antioxidant activities of the monomethylated metabolites and dimethylated metabolites (M2) were evaluated against H2O2-induced oxidative stress damage in HepG2 cells and compared to CA.
Journal ArticleDOI
The anti-inflammatory components from the effective fraction of Syringae Folium (ESF) and its mechanism investigation based on network pharmacology.
TL;DR: The results attained in this study indicated that ESF had the potential to be developed as an anti-inflammation agent applied in clinic.
Journal ArticleDOI
Guanosine-5'-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain.
TL;DR: The mechanism by which GTPCH1 activates microglia and provide new potential targets for microglial activation in neuropathic pain is revealed and five lncRNAs related to the downregulation of Mapk14 mRNA expression are revealed.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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