Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Vitamin B complex suppresses neuroinflammation in activated microglia: in vitro and in silico approach combined with dynamical modeling.
Tanja Lunić,Marina Bekić,Sergej Tomić,Katarina Mitić,Stefan Graovac,Bojan Božič,Biljana Božić Nedeljković +6 more
TL;DR: In this paper , the anti-inflammatory effects of the vitamin B complex (VBC) on the function and phenotype of lipopolysaccharide (LPS)-stimulated BV2 microglial cells were examined in vitro.
Journal ArticleDOI
Utilization of experimental design in the formulation and optimization of hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil nanoemulsion for gingivitis
Amal M. Sindi,Khaled M. Hosny,Waleed Y. Rizg,Fahad Y. Sabei,Osama Madkhali,Mohammed Ali Bakkari,Eman Saud Alfayez,Hanaa Alkharobi,Samar A. Alghamdi,Arwa A hmed Banjar,Mohammed Majrashi,Mohammed Alissa +11 more
TL;DR: In this paper , the authors used the response surface Box-Behnken design with different concentrations of CrO (120, 180, and 250 µm), Tur (20, 35, and 50 µm) and Smix 2:1 (400, 500, and 600 µm).
Journal ArticleDOI
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways
Li-jun Huang,Lei Gong,Xue-yan Huo,Liao Lei,Qi Zhang,Yunjie Hu,Qi-Xuan Kuang,Yu-Ran Gui,Yi-Fei Dai,Yu-Cheng Gu,Yun Deng,Daliang Guo +11 more
TL;DR: This study reveals a new role of NADD in inhibiting theTLR4/NF-κB and NLRP3/Caspase-1 pathways, and shows that TLR4-MD2 is the direct target of Nadd, which may provide a potential therapeutic candidate for the treatment of neuroinflammation.
Journal ArticleDOI
Prebiotics modulate the microbiota-gut-brain axis and ameliorate cognitive impairment in APP/PS1 mice.
Shujuan Zhang,Shuang Lv,Yiming Li,Dongfeng Wei,Xiaowei Zhou,Xiaoqian Niu,Zi-Bing Yang,Weiqun Song,Zhanjun Zhang,Dantao Peng +9 more
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Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
TL;DR: In this article , the Wnt/β-catenin signaling pathway in a model of neuroinflammation in Lipopolysaccharide (LPS)/IFN-γ-stimulated BV-2 cells was shown to inhibit production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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