Journal ArticleDOI
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.
Mahban Rahimifard,Faheem Maqbool,Shermineh Moeini-Nodeh,Kamal Niaz,Mohammad Abdollahi,Nady Braidy,Seyed Mohammad Nabavi,Seyed Fazel Nabavi +7 more
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TLDR
It is proposed that natural compounds targeting TLR4 may serve as important pharmacophores for the development of potent drugs for the treatment of neurological disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2017-07-01. It has received 302 citations till now. The article focuses on the topics: Neuroinflammation & Neuroprotection.read more
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Modulation of neuroinflammatory pathways by medicinal mushrooms, with particular relevance to Alzheimer's disease
Naufal Kushairi,Nor Athirah Kamaliah Ahmad Tarmizi,Chia-Wei Phan,Ian Macreadie,Ian Macreadie,Vikineswary Sabaratnam,Murali Naidu,Pamela David +7 more
TL;DR: A review of the anti-neuroinflammatory activities of bioactive components from medicinal mushrooms in various in vitro and in vivo models focuses on the pathological effects on AD, with insights into other neurodegenerative diseases.
Journal ArticleDOI
Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression
Sasimol Udomruk,Chayanut Kaewmool,Peraphan Pothacharoen,Thanyaluck Phitak,Prachya Kongtawelert +4 more
TL;DR: Sesamin alleviated inflammation-induced neurodegeneration via inhibition of TLR4 expression and microglial activation resulting in diminishing the neurotoxicity effect, suggesting that sesamin might be a potential agent for Neurodegenerative diseases prevention.
Journal ArticleDOI
The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.
TL;DR: Icariin prevented ISO-induced TS-like cardiac dysfunction in rats through maintenance of the dynamic balance of the ROS system, promotion of anti-oxidant element activity, and suppression of TLR4/NF-κB signaling pathway protein expression.
Journal ArticleDOI
A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways
Yue Hou,Yue Hou,Yuchen Zhang,Yan Mi,Yan Mi,Jian Wang,Haotian Zhang,Jikai Xu,Jikai Xu,Yanqiu Yang,Jingyu Liu,Lingling Ding,Jingyu Yang,Guoliang Chen,Chunfu Wu +14 more
TL;DR: Results showed that RV 01 suppressed microglia-mediated neuroinflammation and protected neurons from inflammatory damage, which indicates that RV01 has great potential as a nutritional preventive strategy for neuroinflammations-related diseases.
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Ionic Liquid⁻Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity.
TL;DR: IL-UAE could not only obtain higher yield in a shorter time, but also reduce the solvent consumption, and this experiment provides valuable references for further utilization of S. helvetica.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
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