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The New RNA World: Growing Evidence for Long Noncoding RNA Functionality
Allison Jandura,Henry M. Krause +1 more
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TLDR
This Opinion article reemphasizes the unique abilities of RNAs to form myriad structures as well as to interact with other RNAs, DNA, and proteins, which provide them with unique and powerful abilities.About:
This article is published in Trends in Genetics.The article was published on 2017-10-01. It has received 177 citations till now. The article focuses on the topics: Long non-coding RNA & RNA.read more
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Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome.
Maomao Zhang,Yang Zheng,Yong Sun,Shuang Li,Liangqi Chen,Xiangyuan Jin,Xinyu Hou,Xianglan Liu,Qi Chen,Jing Li,Mingyang Liu,Xianghui Zheng,Yongxiang Zhang,Jian Wu,Bo Yu +14 more
TL;DR: The results indicate thatNEAT1 knockdown in DCs can induce immune tolerance in models of experimental autoimmune myocarditis and heart transplantation and highlights the therapeutic potential of targeting NEAT1 for the treatment of immune-related diseases.
Journal ArticleDOI
A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation.
Hui Miao,Linlin Wang,Haomiao Zhan,Jiangshan Dai,Yanbo Chang,Fan Wu,Tao Liu,Zhongyu Liu,Chunfang Gao,Li Ling,Xu Song +10 more
TL;DR: A mechanism whereby an lncRNA works at different cellular compartments to regulate the pro-apoptotic gene PYCard at both the epigenetic and translational levels, contributing to the PYCARD-regulated apoptosis is revealed and new light is shed on the role of discretely distributed lncRNAs in diverse biological processes.
Journal ArticleDOI
Long Noncoding RNAs and Repetitive Elements: Junk or Intimate Evolutionary Partners?
TL;DR: A new look is taken at the evidence for and against widespread noncoding gene functionality and the suggestion put forward is that more of this junk DNA may be functional than nonfunctional and that nonc coding RNAs and transposable elements act symbiotically to drive evolution.
Journal ArticleDOI
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.
TL;DR: This study identified that a small chemical molecule, 3-benzyl-5-([2-nitrophenoxy] methyl)-dihydrofuran-2(3H)-one (3BDO), synthesized by us, could inhibit VEC autophagy and apoptosis induced by a high concentration of glucose.
Journal ArticleDOI
Circulating lncRNA XLOC_009167 serves as a diagnostic biomarker to predict lung cancer
Nan Jiang,Xiaodan Meng,Hongchao Mi,Yidi Chi,Shenghui Li,Zeyu Jin,Hui Tian,Jinxian He,Weiyu Shen,Haihua Tian,Jinchang Pan,Shuai Fang,Xiaofeng Jin,Chengwei Zhou,Zhaohui Gong +14 more
TL;DR: Intriguingly, the ROC showed lncRNA XLOC_009167 was a better diagnostic potential compared to the traditional biomarkers (CYFR21-1, NSE and CA72-4), and the circulating lncRNAs were found to be stable in whole blood under different conditions.
References
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
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A gene complex controlling segmentation in Drosophila.
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The Transcriptional Landscape of the Mammalian Genome
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TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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