The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Genomic characterization and phylogenetic analysis of SARS-COV-2 in Italy.
Gianguglielmo Zehender,Alessia Lai,Annalisa Bergna,Luca Meroni,Agostino Riva,Claudia Balotta,Maciej Tarkowski,Arianna Gabrieli,Dario Bernacchia,Stefano Rusconi,Giuliano Rizzardini,Spinello Antinori,Massimo Galli +12 more
TL;DR: Early molecular epidemiological tracing suggests that SARS‐CoV‐2 was present in Italy weeks before the first reported cases of infection.
Journal ArticleDOI
COVID-19: Complement, Coagulation, and Collateral Damage.
TL;DR: A summary of CO VID-19 is provided and complement’s role in COVID-19 acute respiratory distress syndrome and coagulopathy is reviewed, suggesting that the complement system plays a key role in this inflammatory reaction.
Journal ArticleDOI
Susceptibility of Raccoon Dogs for Experimental SARS-CoV-2 Infection.
Conrad M. Freuling,Angele Breithaupt,Thomas Müller,Julia Sehl,Anne Balkema-Buschmann,Melanie Rissmann,Antonia Klein,Claudia Wylezich,Dirk Höper,Kerstin Wernike,Andrea Aebischer,Donata Hoffmann,Virginia Friedrichs,Anca Dorhoi,Martin H. Groschup,Martin Beer,Thomas C. Mettenleiter +16 more
TL;DR: It is demonstrated susceptibility of raccoon dogs to severe acute respiratory syndrome coronavirus 2 infection and transmission to in-contact animals and virus replication and tissue lesions occurred in the nasal conchae.
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The potential effects of widespread community transmission of SARS-CoV-2 infection in the World Health Organization African Region: a predictive model.
Joseph Cabore,Humphrey Karamagi,Hillary Kipruto,James Avoka Asamani,Benson Droti,Aminata Binetou Wahebine Seydi,Regina Titi-Ofei,Benido Impouma,Michel Yao,Zabulon Yoti,Felicitas Zawaira,Prosper Tumusiime,Ambrose Talisuna,Francis Kasolo,Matshidiso Moeti +14 more
TL;DR: The results predict a high risk of exposure in states of small size, together with Algeria, South Africa and Cameroon, and Nigeria will have the largest number of infections, followed by Algeria and South Africa, and Mauritania would have the fewest cases.
Journal ArticleDOI
Trends in Intensive Care for Patients with COVID-19 in England, Wales and Northern Ireland.
James C Doidge,Doug W Gould,Paloma Ferrando-Vivas,Paul R Mouncey,Karen Thomas,Manu Shankar-Hari,Manu Shankar-Hari,David A Harrison,Kathryn M Rowan +8 more
TL;DR: The population of patients with COVID-19 admitted to ICU, and the processes of care in ICUs, changed over the first wave of the epidemic, and after adjustment for important risk factors, there was a substantial improvement in patient outcomes.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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