The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses.
M. Khalid Ijaz,M. Khalid Ijaz,Raymond W. Nims,Sifang Steve Zhou,Kelly Whitehead,Vanita Srinivasan,Tanya Kapes,Semhar Fanuel,Jonathan H. Epstein,Peter Daszak,Joseph R. Rubino,Julie McKinney +11 more
TL;DR: In this article, the authors evaluated the efficacy of formulated microbicidal actives against alpha and beta-coronaviruses, including SARS-CoV-2.
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Dysregulated naive B cells and de novo autoreactivity in severe COVID-19
Matthew C. Woodruff,Richard P. Ramonell,Natalie S. Haddad,Fabliha Anam,Mark E. Rudolph,Tiffany A Walker,Alexander D. Truong,Adviteeya Narasimhan Dixit,Jenny E. Han,Monica Cabrera-Mora,Martin Runnstrom,Regina Bugrovsky,Jennifer R. Hom,Erin C Connolly,Igor Albizua,Vidhi Javia,Kevin S. Cashman,Doan C. Nguyen,Shuya Kyu,Ankur Singh Saini,Michael Piazza,Christopher M. Tipton,Arezou Khosroshahi,Greg Gibson,Greg S. Martin,Cheryl L. Maier,Annette M. Esper,Scott A. Jenks,F. Eun-Hyung Lee,Ignacio Sanz +29 more
TL;DR: In this article , the authors identify the expansion of a naive-derived, low-mutation IgG1 population of antibody-secreting cells (ASCs) reflecting features of low selective pressure.
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In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2
Edoardo Milanetti,Edoardo Milanetti,Mattia Miotto,Lorenzo Di Rienzo,Madhu Nagaraj,Michele Monti,Thaddeus W. Golbek,Giorgio Gosti,Steven J. Roeters,Tobias Weidner,Daniel E. Otzen,Giancarlo Ruocco +11 more
TL;DR: In this article, a numerical method based on the representation of the molecular isoelectronic density surface in terms of 2D Zernike polynomials was proposed to determine the relationship of complementarity between portions of protein surfaces.
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Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset.
Juan Francisco Gutiérrez-Bautista,Antonio Rodriguez-Nicolas,Antonio Rosales-Castillo,Pilar Jiménez,Federico Garrido,Per Anderson,Francisco Ruiz-Cabello,Miguel Ángel López-Ruz +7 more
TL;DR: The nature of the lymphopenia is characterized and a set of factors that hinder the effective control of virus infection and the activation and arming of effector cytotoxic T CD8 cells are demonstrated, showing signatures defining a high-risk population.
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SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing.
Alistair V.W. Nunn,Geoffrey Guy,Wolfgang Brysch,Stanley W. Botchway,Wayne D. Frasch,Edward J. Calabrese,Jimmy D. Bell +6 more
TL;DR: The data that might support the idea that mitochondrial health, induced by a healthy lifestyle, could be a key factor in resisting the virus, and for those people who are perhaps not in optimal health, treatments that could support mitochondrial function might be pivotal to their long-term recovery are reviewed.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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