The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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COVID-19 and ART: the view of the Italian Society of Fertility and Sterility and Reproductive Medicine.
Alberto Vaiarelli,Carlo Bulletti,Danilo Cimadomo,Andrea Borini,Carlo Alviggi,Silvia Ajossa,Paola Anserini,Gianluca Gennarelli,Maurizio Guido,Paolo E. Levi-Setti,Antonio Palagiano,Roberto Palermo,Valeria Savasi,Antonio Pellicer,Laura Rienzi,Filippo Maria Ubaldi +15 more
TL;DR: The position of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) in outlining ART priorities during and after this emergency is represented.
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Techno-economic review on short-term anthropogenic emissions of air pollutants and particulate matter
Manigandan Sekar,T.R. Praveen Kumar,M. Selva Ganesh Kumar,Radka Vaníčková,Josef Maroušek,Josef Maroušek +5 more
TL;DR: In this paper, a plethora of case studies have been published mapping the environmental impacts in specific locations in terms of changes in wastewater composition, noise, solar radiation and more, and the most urgent question is whether artificially inducing such a pandemic could be justified, given the loss of human life and economic losses.
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Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Shona C Moore,Rebekah Penrice-Randal,Muhannad Alruwaili,Nadine Randle,Stuart D. Armstrong,Catherine Hartley,Sam Haldenby,Xiaofeng Dong,Abdulrahman Alrezaihi,Mai Almsaud,Eleanor G. Bentley,Jordan J. Clark,Isabel García-Dorival,Paul Gilmore,Ximeng Han,Benjamin Jones,Lisa Luu,Parul Sharma,Ghada Shawli,Yani Sun,Qin Zhao,Steven T. Pullan,Daniel P. Carter,Kevin R. Bewley,Jake Dunning,En-Min Zhou,Tom Solomon,Michael Beadsworth,James Cruise,Derrick W. Crook,David A. Matthews,Andrew D. Davidson,Zana H. Mahmood,Waleed Aljabr,Julian Druce,Richard Vipond,Lisa Ng,Laurent Renia,Peter J. M. Openshaw,J Kenneth Baillie,Miles W. Carroll,James P. Stewart,Alistair C. Darby,Malcolm G Semple,Lance Turtle,Julian A. Hiscox +45 more
TL;DR: A long amplicon/read length-based RT-PCR sequencing approach focused on the Oxford Nanopore MinION/GridION platforms was developed and proved sensitive in identifying viral RNA in samples from patients that had been declared negative using other nucleic acid-based assays (false negative).
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Considerations for the development of cost-effective cell culture media for cultivated meat production.
TL;DR: The present review shall provide an overview of the current understanding of cell culture media as it relates to cultivated meat.
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Recent insights for the emerging COVID-19: drug discovery, therapeutic options and vaccine development.
TL;DR: The present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for CO VID-19 as well as some insightful discussions of the status of COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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