The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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CRISPR-Cas System: An Approach With Potentials for COVID-19 Diagnosis and Therapeutics.
Prashant Kumar,Yashpal Singh Malik,Balasubramanian Ganesh,Somnath Rahangdale,Somnath Rahangdale,Sharad Saurabh,Senthilkumar Natesan,Ashish Srivastava,Khan Sharun,Mohd Iqbal Yatoo,Ruchi Tiwari,Raj Kumar Singh,Kuldeep Dhama +12 more
TL;DR: Potential use and challenges of CRISPR-Cas based approaches for the development of rapid and accurate diagnostic technique and/or a possible therapeutic alternative for combating COVID-19 are described.
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Atlas of ACE2 gene expression in mammals reveals novel insights in transmisson of SARS-Cov-2
TL;DR: Through building the first atlas of ACE2 expression in pets and livestock, this work identified species and tissues susceptible to SARS-CoV-2 infection, yielding novel insights into the viral transmission.
Posted ContentDOI
Modeling the COVID-19 outbreaks and the effectiveness of the containment measures adopted across countries
TL;DR: It is argued that the idea of "flattening the curve" to reach herd immunity is likely to be unfeasible, and that a progressive strengthening of these measures usually reduces the R_0 below 1, granting a decay of the outbreak.
Journal ArticleDOI
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
Rachid Essalmani,Jaspreet Jain,Delia Susan-Resiga,Ursula Andreo,Alexandra Evagelidis,Rabeb Mouna Derbali,David N. Huynh,Frederick Dallaire,Mélanie Laporte,Adrien Delpal,Priscila Sutto-Ortiz,Bruno Coutard,Claudine E. Mapa,Keith M. Wilcoxen,Etienne Decroly,Tram Nq Pham,Eric A. Cohen,Nabil G. Seidah +17 more
TL;DR: It is suggested that the combination of a nontoxic furin inhibitor with a TMPRSS2 inhibitor significantly reduces viral entry in lung cells, as evidenced by an average synergistic ∼95% reduction of viral infection.
Journal ArticleDOI
Prediction modelling of COVID using machine learning methods from B-cell dataset.
Nikita Jain,Srishti Jhunthra,Harshit Garg,Vedika Gupta,Senthilkumar Mohan,Ali Ahmadian,Ali Ahmadian,Soheil Salahshour,Massimiliano Ferrara +8 more
TL;DR: In this article, the authors used various machine learning models, such as SVM, Naive Bayes, K-nearest neighbors, AdaBoost, Gradient boosting, XGBoost, Random Forest, ensembles, and neural networks, to predict SARS-CoV and SARS CoV-2.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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