The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2
Xuesen Zhao,Shuangli Zheng,Danying Chen,Mei Zheng,Xinglin Li,Guoli Li,Hanxin Lin,Jinhong Chang,Hui Zeng,Ju-Tao Guo +9 more
TL;DR: The work reported herein demonstrates that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis via a distinct mechanism and sheds new light on the immunopathogenesis of human coronavirus infection.
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Early transmission of SARS-CoV-2 in South Africa: An epidemiological and phylogenetic report
Jennifer Giandhari,Sureshnee Pillay,Eduan Wilkinson,Houriiyah Tegally,Ilya Sinayskiy,Maria Schuld,José Lourenço,Benjamin Chimukangara,Richard J Lessells,Yunus Moosa,Inbal Gazy,Maryam Fish,Lavanya Singh,Khulekani Sedwell Khanyile,Vagner Fonseca,Marta Giovanetti,Luiz Carlos Junior Alcantara,Francesco Petruccione,Tulio de Oliveira +18 more
TL;DR: It is demonstrated that early transmission in KZN, and most probably in all main regions of SA, was associated with multiple international introductions and dominated by lineages B1 and B, which provides potential explanations for the initially high death rates in the province.
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New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release
Tre Tomaszewski,Ryan S. DeVries,Mengyi Dong,Gitanshu Bhatia,Miles D. Norsworthy,Xuying Zheng,Gustavo Caetano-Anollés +6 more
TL;DR: The genomic accumulation of mutations at various time points of the early pandemic is investigated to identify changes in mutationally highly active genomic regions that are occurring worldwide and predicts an ongoing mutational shift from the spike and replication complex to other regions.
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Review on Up-to-Date Status of Candidate Vaccines for COVID-19 Disease
TL;DR: In this paper, the authors highlight the different approaches and technologies used around the world for the design and development of the vaccines and also focus on the recent status of the SARS-CoV-2 vaccine candidates under development by various institutions to combat the world threat of COVID-19 pandemic.
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Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Shruti Koulgi,Vinod Jani,Mallikarjunachari V. N. Uppuladinne,Uddhavesh Sonavane,Rajendra Joshi +4 more
TL;DR: The binding of remdesivir to RdRP of SARS-CoV-2 has been studied using the classical molecular dynamics and ensemble docking approach and information on crucial interactions between conserved residues of RdRP with remdesvir through in silico approaches may be useful in designing inhibitors.
References
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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