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The proximal origin of SARS-CoV-2.

Kristian G. Andersen, +5 more
- 01 Apr 2020 - 
- Vol. 26, Iss: 4, pp 450-452
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.
Abstract: 
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.

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Posted ContentDOI

Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

Rahila Sardar, +4 more
- 21 Mar 2020 - 
TL;DR: An integrated sequence-based analysis of SARS-CoV2 genomes from different geographical locations is performed in order to identify its unique features, conferring unique infection, facilitation of transmission, virulence and immunogenic features to the virus.
Journal ArticleDOI

SARS-CoV-2 pandemic: a review of molecular diagnostic tools including sample collection and commercial response with associated advantages and limitations.

Harikrishnan Jayamohan, +9 more
- 01 Jan 2021 - 
TL;DR: This work puts forth key observations in the functionality of current methods for SARS-CoV-2 diagnostic testing, which include nucleic acid amplification–, CRISPR-, sequencing-, antigen-, and antibody-based detection methods.
Journal ArticleDOI

The potential application of electrochemical biosensors in the COVID-19 pandemic: A perspective on the rapid diagnostics of SARS-CoV-2.

Sahar Sadat Mahshid, +2 more
- 15 Mar 2021 - 
TL;DR: Advances in electrochemical biosensing platforms towards the detection of SARS-CoV-2 through studying similar viruses are reviewed.
Journal ArticleDOI

Citizens' Adherence to COVID-19 Mitigation Recommendations by the Government: A 3-Country Comparative Evaluation Using Web-Based Cross-Sectional Survey Data.

Abrar Al-Hasan, +2 more
- 11 Aug 2020 - 
TL;DR: A comparative evaluation of citizens’ adherence process to COVID-19–relevant recommendations by the government finds that the government plays a central role in terms of adherence to restrictions.
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Direct Observation of Repeated Infections With Endemic Coronaviruses.

Marta Galanti, +1 more
- 13 Feb 2021 - 
TL;DR: This study provides evidence that reinfections with the same endemic coronavirus are not atypical in a time window shorter than 1 year and that the genetic basis of innate immune response may be a greater determinant of infection severity than immune memory acquired after a previous infection.
References
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Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

A new coronavirus associated with human respiratory disease in China.

Fan Wu, +20 more
- 03 Feb 2020 - 
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
Journal ArticleDOI

An interactive web-based dashboard to track COVID-19 in real time.

Ensheng Dong, +2 more
- 01 May 2020 - 
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Daniel Wrapp, +7 more
- 13 Mar 2020 - 
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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