The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Insights on cross-species transmission of SARS-CoV-2 from structural modeling.
João P. G. L. M. Rodrigues,Susana Barrera-Vilarmau,João M.C. Teixeira,Marija Sorokina,Elizabeth Seckel,Panagiotis L. Kastritis,Michael Levitt +6 more
TL;DR: The structural properties of several ACE2 orthologs bound to the SARS-CoV-2 spike protein are investigated and a blueprint for modeling viral-host protein interactions is provided and several important considerations are highlighted when designing these computational studies and analyzing their results.
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Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19.
TL;DR: To avoid or mitigate the dire consequences of this and future pandemics, unraveling the origins of SARS-CoV-2 and COVID-19 will be essential—even though a definitive answer may be elusive, and an objective analysis means broaching some uncomfortable possibilities.
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Pharmacophore based virtual screening, molecular docking, molecular dynamics and MM-GBSA approach for identification of prospective SARS-CoV-2 inhibitor from natural product databases.
Banoth Karan Kumar,Faheem,Kondapalli Venkata Gowri Chandra Sekhar,Rupal Ojha,Vijay Kumar Prajapati,Aravinda Pai,Sankaranarayanan Murugesan +6 more
TL;DR: The computational study identified several ligands that may act as potential inhibitors of SARS-CoV-2 Mpro.2 and the top-ranked molecules SN00293542, and SN00382835 occupied the active site of the target, the main protease like that of the co-crystal ligand.
Journal ArticleDOI
One year of SARS-CoV-2: Genomic characterization of COVID-19 outbreak in Qatar
Fatiha M. Benslimane,Hebah A. AlKhatib,Ola Al-Jamal,Dana Albatesh,Sonia Boughattas,Ayeda A. Ahmed,Meryem Bensaad,Shameem Younuskunju,Yasmin A. Mohamoud,Mashael Al Badr,Abdalla A. Mohamed,Reham A. El Kahlout,Tasneem Al Hamad,Dina Elgakhlab,Fatima H. Al-Kuwari,Chadi Saad,Andrew Jeremijenko,Abdullatif Al-Khal,Muna Almaslamani,Roberto Bertollini,Einas Alkuwari,Hamad Al-Romaihi,Salih A. Al-Marri,Mohammed Al-Thani,Radja Badji,Hamdi Mbarek,Yasser Al-Sarraj,Joel A. Malek,Said I. Ismail,Laith J. Abu-Raddad,Laith J. Abu-Raddad,Peter Coyle,Asmaa Althani,Hadi M. Yassine,Hadi M. Yassine +34 more
TL;DR: In this paper, the authors report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March-2021, representing 1.5% of all positive cases in this period.
Journal ArticleDOI
The ongoing COVID-19 epidemic in Minas Gerais, Brazil: insights from epidemiological data and SARS-CoV-2 whole genome sequencing.
Joilson Xavier,Marta Giovanetti,Marta Giovanetti,Talita Émile Ribeiro Adelino,Vagner Fonseca,Vagner Fonseca,Alana Vitor Barbosa da Costa,Adriana Aparecida Ribeiro,Katlin Nascimento Felicio,Clara Guerra Duarte,Marcos Vieira Silva,Álvaro Salgado,Mauricio Teixeira Lima,Ronaldo de Jesus,Allison Fabri,Cristiane Franco Soares Zoboli,Thales Gutemberg Souza Santos,Felipe Campos de Melo Iani,Massimo Ciccozzi,Ana Maria Bispo de Filippis,Marilda M. Siqueira,André Luiz de Abreu,Vasco de Azevedo,Dario Brock Ramalho,Carlos F. Campelo de Albuquerque,Tulio de Oliveira,Edward C. Holmes,José Lourenço,Luiz Carlos Junior Alcantara,Luiz Carlos Junior Alcantara,Marluce Aparecida Assunção Oliveira +30 more
TL;DR: The estimated date of SARS-CoV-2 introduction into Brazil was consistent with epidemiological data from the first case of a returned traveller from Lombardy, Italy and the need for real-time and continued genomic surveillance strategies to better understand and prepare for the epidemic spread of emerging viral pathogens is reinforced.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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