The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
Citations
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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Joana Damas,Graham M. Hughes,Kathleen C. Keough,Corrie A. Painter,Nicole S. Persky,Marco Corbo,Michael Hiller,Klaus-Peter Koepfli,Andreas R. Pfenning,Huabin Zhao,Huabin Zhao,Diane P. Genereux,Ross Swofford,Katherine S. Pollard,Oliver A. Ryder,Martin T. Nweeia,Martin T. Nweeia,Martin T. Nweeia,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Emma C. Teeling,Elinor K. Karlsson,Elinor K. Karlsson,Harris A. Lewin +23 more
TL;DR: A large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins are identified to assist the identification of intermediate hosts for Sars-Cov-2 and hence reduce the opportunity for a future outbreak of COVID-19.
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COVID-19 vaccine development and a potential nanomaterial path forward.
Matthew D Shin,Sourabh Shukla,Young Hun Chung,Veronique Beiss,Soo Khim Chan,Oscar A Ortega-Rivera,David M. Wirth,Angela Chen,Markus Sack,Jonathan K. Pokorski,Nicole F. Steinmetz +10 more
TL;DR: Current approaches to COVID-19 vaccine development are highlighted, highlighting the role of nanotechnology, manufacturing and distribution and a successful vaccine platform must enable rapid discovery, scalable manufacturing and global distribution.
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The COVID-19 pandemic: A comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control
Yosra A. Helmy,Yosra A. Helmy,Mohamed Fawzy,Ahmed Elaswad,Ahmed Sobieh,Scott P. Kenney,Awad A. Shehata +6 more
TL;DR: A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market, producing the disease named coronavirus disease-2019 (COVID-19), which the WHO has declared a pandemic.
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An Update on Current Therapeutic Drugs Treating COVID-19.
Renyi Wu,Lujing Wang,Hsiao-Chen Dina Kuo,Ahmad Shannar,Rebecca Peter,Pochung Jordan Chou,Shanyi Li,Rasika Hudlikar,Xia Liu,Xia Liu,Zhigang Liu,George J. Poiani,George J. Poiani,Louis F. Amorosa,Luigi Brunetti,Luigi Brunetti,Ah-Ng Tony Kong +16 more
TL;DR: It is hoped that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.
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SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology.
Natacha S. Ogando,Tim J. Dalebout,Jessika C. Zevenhoven-Dobbe,Ronald W. A. L. Limpens,Yvonne van der Meer,Leon Caly,Julian Druce,Jutte J.C. de Vries,Marjolein Kikkert,Montserrat Bárcena,Igor A. Sidorov,Eric J. Snijder +11 more
TL;DR: The sensitivity of the two viruses to three established inhibitors of coronavirus replication is very similar, but that SARS-CoV-2 infection was substantially more sensitive to pre-treatment of cells with pegylated interferon alpha.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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