The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study.
Tessa Prince,Shirley L Smith,Alan D Radford,Tom Solomon,Tom Solomon,Grant L. Hughes,Grant L. Hughes,Edward I Patterson +7 more
TL;DR: A thorough examination of the current knowledge and evidence of the ability of SARS-CoV-2 to infect different animal species is therefore vital to evaluate the threat of animal to human transmission and reverse zoonosis.
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A novel bat coronavirus reveals natural insertions at the S1/S2 cleavage site of the Spike protein and a possible recombinant origin of HCoV-19
Hong Zhou,Xing Chen,Tao Hu,Juan Li,Hao Song,Yanran Liu,Peihan Wang,Di Liu,Jing Yang,Edward C. Holmes,Alice C. Hughes,Yuhai Bi,Weifeng Shi +12 more
TL;DR: Data suggest that HCoV-19 originated from multiple naturally occurring recombination events among those viruses present in bats and other wildlife species.
Journal ArticleDOI
A "One-Health" approach for diagnosis and molecular characterization of SARS-CoV-2 in Italy.
Alessio Lorusso,Paolo Calistri,Maria Teresa Mercante,Federica Monaco,Ottavio Portanti,Maurilia Marcacci,Cesare Cammà,Antonio M. Rinaldi,Iolanda Mangone,Adriano Di Pasquale,Marino Iommarini,Maria Mattucci,Paolo Fazii,Pierluigi Tarquini,Rinalda Mariani,Alessandro Grimaldi,Daniela Morelli,Giacomo Migliorati,Giovanni Savini,Silvio Borrello,Nicola D'Alterio +20 more
TL;DR: The experience that veterinarians operating within the Public health system gained in the control and characterization of previous health issues of livestock and poultry including avian flu, bluetongue, foot and mouth disease, is certainly of great help to minimize the impact of this global crisis.
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Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development
TL;DR: In this paper, the authors discussed the effects of novel mutations in the SARS-CoV-2 genome on transmission, clinical outcomes and vaccine development, and the impact of the mutation on the rate of transmission between people, disease severity and the vaccine and therapeutic development.
Journal ArticleDOI
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function
TL;DR: The finding that the gene encoding Spike protein has been a target of both purifying and positive selection within the genome of SARS-CoV-2 is recapitulate and a test for branch-specific oversubstitution of mutations within narrow windows of the genome without reference to the genetic code is applied.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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