The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection.
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TL;DR: The way in which SARS-CoV-2 spreads, how to diagnose a novel corona virus infection, what the possible treatments are, and which protective personal equipment the authors can use to stop its spreading are made.
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Effects of Physical Distancing to Control COVID-19 on Public Health, the Economy, and the Environment.
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SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics.
Ruchir Gupta,Jacob G Charron,Jacob G Charron,Cynthia L. Stenger,Jared Painter,Hunter Steward,Taylor W Cook,William Faber,Austin Frisch,Eric Lind,Jacob Bauss,Xiaopeng Li,Olivia Sirpilla,Olivia Sirpilla,Xavier Soehnlen,Xavier Soehnlen,Adam Underwood,David A. Hinds,Michele I. Morris,Neil E. Lamb,Joseph A. Carcillo,Caleb Bupp,Bruce D. Uhal,Surender Rajasekaran,Surender Rajasekaran,Surender Rajasekaran,Jeremy W. Prokop +26 more
TL;DR: It is proposed that this SARS-CoV-2 database may aid research into the ongoing pandemic and facilitate future discoveries and educational use of VIStEDD for nsp6, nucleocapsid (N), and spike (S) surface glycoprotein.
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A novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China.
Lili Li,Jinglin Wang,Xiao-hua Ma,Xiaoman Sun,Jinsong Li,Xiao-fei Yang,Weifeng Shi,Zhao-jun Duan +7 more
TL;DR: In 2019, a new type of beta-CoV, SARS-coV-2 emerged and triggered the COVID-19 pandemic, which spread overwhelmingly around the world in less than a year.
References
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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