The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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N- and O-Glycosylation of the SARS-CoV-2 Spike Protein.
TL;DR: In this paper, the SARS-CoV-2 spike (S) protein was observed to be O-glycosylated on a threonine (T678) near the furin cleavage site occupied by core-1 and core-2 structures.
Journal ArticleDOI
Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.
Zhe Liu,Huanying Zheng,Huifang Lin,Mingyue Li,Runyu Yuan,Jinju Peng,Qianling Xiong,Jiufeng Sun,Baisheng Li,Jie Wu,Lina Yi,Xiaofang Peng,Huan Zhang,Wei Zhang,Ruben J.G. Hulswit,Nicholas J. Loman,Andrew Rambaut,Changwen Ke,Thomas A. Bowden,Oliver G. Pybus,Oliver G. Pybus,Jing Lu +21 more
TL;DR: There may be distinct selection pressures on SARS-CoV-2 replication or infection in vitro and in vivo; an efficient mechanism for deleting this region from the viral genome may exist, given that the deletion variant is commonly detected after two rounds of cell passage.
Journal ArticleDOI
Misinformation about COVID-19: evidence for differential latent profiles and a strong association with trust in science.
Jon Agley,Yunyu Xiao,Yunyu Xiao +2 more
TL;DR: In this paper, the authors conducted a survey to identify factors associated with membership in specific COVID-19 narrative believability profiles, including political orientation, religious commitment, and trust in science, along with sociodemographic items.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection.
Aleksandra Synowiec,Artur Szczepanski,Emilia Barreto-Duran,Laurensius Kevin Lie,Krzysztof Pyrc +4 more
TL;DR: Wang et al. as discussed by the authors summarized existing data on the replication of SARS-CoV-2 in different tissues in both patients and ex vivo models, and the following question arises: is COVID-19 a respiratory or systemic disease?
Journal ArticleDOI
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Helena Winstone,Maria Jose Lista,Alisha C. Reid,Clement Bouton,Suzanne Pickering,Rui Pedro Galão,Claire Kerridge,Katie J. Doores,Chad M. Swanson,Stuart J. D. Neil +9 more
TL;DR: In this paper, the authors investigated the relevance of the polybasic cleavage site in the route of entry of SARS-CoV-2 and the consequences this has for sensitivity to interferons (IFNs) and specifically the IFN-induced transmembrane (IFITM) protein family that inhibit entry of diverse enveloped viruses.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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