The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Molecular analysis of several in-house rRT-PCR protocols for SARS-CoV-2 detection in the context of genetic variability of the virus in Colombia.
Diego A. Álvarez-Díaz,Carlos Franco-Muñoz,Katherine Laiton-Donato,José A. Usme-Ciro,Nicolás D. Franco-Sierra,Astrid Carolina Flórez,Sergio Gómez Rangel,Luz D. Rodríguez-Calderon,Juliana Barbosa-Ramirez,Erika Ospitia-Baez,Diana M. Walteros,Martha Lucia Ospina Martínez,Marcela Mercado-Reyes +12 more
TL;DR: The genomic surveillance of SARS-CoV-2 is highly recommended for the early identification of mutations in critical regions and to issue recommendations on specific diagnostic tests to ensure the coverage of locally-circulating genetic variants.
Journal ArticleDOI
Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain.
Austen Bernardi,Yihan Huang,Bradley S Harris,Yongao Xiong,Somen Nandi,Karen A. McDonald,Roland Faller +6 more
TL;DR: These models are tested in their interaction with a fragment of the receptor-binding domain of the Spike Protein S of the SARS-CoV-2 virus, and it is seen that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor.
Journal ArticleDOI
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model.
TL;DR: In this article, the authors proposed a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans.
Journal ArticleDOI
Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status.
Narasimha M Beeraka,Surya P. Sadhu,SubbaRao V. Madhunapantula,Rajeswara Rao Pragada,Andrey A. Svistunov,Vladimir N. Nikolenko,Vladimir N. Nikolenko,Liudmila M. Mikhaleva,Gjumrakch Aliev +8 more
TL;DR: Structural features of SARS-CoV-2 are reviewed with special emphasis on key molecular targets and their known modulators that can be considered for the development of novel small molecule inhibitors (NSMIs) that can interfere with viral entry or viral propagation.
Journal ArticleDOI
Testing three explanations for stigmatization of people of Asian descent during COVID-19: maladaptive coping, biased media use, or racial prejudice?
TL;DR: Efforts to reduce stigmatization should address racial stereotypes and emotions, maladaptive coping, and biased media use by providing education and resources to the public, and fostering collective efficacy and media-based contacts with Asian Americans can facilitate these efforts.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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