The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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COVID-19 pandemic: an overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics.
TL;DR: Several antivirals, antimalarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated and shown promising results.
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Decline in Mobility: Public Transport in Poland in the time of the COVID-19 Pandemic
TL;DR: In this paper, the authors assess changes in mobility in public transport in Poland, as a consequence of the development of the COVID-19 pandemic, as well as the stringency of the Polish government's anti-COVID19 policy.
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Direct RNA sequencing and early evolution of SARS-CoV-2
George Taiaroa,George Taiaroa,Daniel Rawlinson,Leo Featherstone,Miranda E. Pitt,Leon Caly,Julian Druce,Damian F. J. Purcell,Leigh Harty,Thomas Tran,Jason Roberts,Nichollas E. Scott,Mike Catton,Deborah A Williamson,Deborah A Williamson,Lachlan J. M. Coin,Sebastián Duchêne +16 more
TL;DR: Parts of coronavirus evolutionary genetics revealed from data are described, and the first direct RNA sequence of SARS-CoV-2 is provided, detailing coronaviral subgenome-length mRNA architecture.
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Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients.
Yang Li,Yang Li,Ming-liang Ma,Qing Lei,Feng Wang,Wei Hong,Dan-yun Lai,Hongyan Hou,Zhaowei Xu,Bo Zhang,Hong Chen,Caizheng Yu,Jun-biao Xue,Yun-xiao Zheng,Xue-ning Wang,He-wei Jiang,Hai-nan Zhang,Huan Qi,Shu-Juan Guo,Yandi Zhang,Xiaosong Lin,Zongjie Yao,Jiaoxiang Wu,Huiming Sheng,Yanan Zhang,Hongping Wei,Ziyong Sun,Xionglin Fan,Sheng-Ce Tao +28 more
TL;DR: In this paper, a linear epitope landscape of the Spike protein was generated by analyzing the serum immunoglobulin G (IgG) response of 1,051 coronavirus disease 2019 (COVID-19) patients with a peptide microarray.
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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates.
Joana Damas,Graham M. Hughes,Kathleen C. Keough,Corrie A. Painter,Nicole S. Persky,Marco Corbo,Michael Hiller,Klaus-Peter Koepfli,Andreas R. Pfenning,Huabin Zhao,Diane P. Genereux,Ross Swofford,Katherine S. Pollard,Oliver A. Ryder,Martin T. Nweeia,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Emma C. Teeling,Elinor K. Karlsson,Elinor K. Karlsson,Harris A. Lewin +20 more
TL;DR: A protein structural analysis was employed to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 binding, and found the number of predicted unfavorable changes significantly correlated with the binding score.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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