The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19.
Franklin W.N. Chow,Tony T.Y. Chan,Anthony Raymond Tam,Suhui Zhao,Weiming Yao,Joshua Fung,Flora Ka Kei Cheng,George C.S. Lo,Stella Chu,Kam Leng Aw-Yong,James Y. M. Tang,Chi-Ching Tsang,Hayes K.H. Luk,Antonio C.P. Wong,Kenneth S.M. Li,Longchao Zhu,Zirong He,Emily Wan Ting Tam,Tom Wai-Hin Chung,Sally C. Y. Wong,Tak-Lun Que,Kitty S. C. Fung,David Christopher Lung,Alan Ka Lun Wu,Ivan Hung,Patrick C. Y. Woo,Susanna K. P. Lau +26 more
TL;DR: This inexpensive, highly sensitive and specific COVID-19-LAMP assay can be useful for rapid deployment as mobile diagnostic units to resource-limiting areas for point-of-care diagnosis, and for unlimited high-throughput mass screening at borders to reduce cross-regional transmission.
Journal ArticleDOI
SARS-CoV-2: from its discovery to genome structure, transcription, and replication
TL;DR: SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS) as discussed by the authors, which has a single-stranded, positive-sense RNA (+RNA) genome of 29.9 kb and exhibits significant genetic shift from different isolates.
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Humoral Immune Responses in COVID-19 Patients: A Window on the State of the Art.
TL;DR: There is urgent need to characterize the virus and the viral-mediated responses, in order to develop specific diagnostic and therapeutic tools to prevent viral transmission and efficiently cure COVID-19 patients.
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Psychological correlates of COVID-19 conspiracy beliefs and preventive measures: Evidence from Turkey.
TL;DR: This article investigated individual differences associated with COVID-19 conspiracy beliefs; whether such conspiracy beliefs are related to the level of compliance with preventive measures; and other individual differences that might be related to preventive measures Higher faith in intuition, uncertainty avoidance, impulsivity, generic conspiracy beliefs, religiosity, and right-wing ideology, and a lower level of cognitive reflection were associated with a higher level of belief in conspiracy theories.
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SARS-CoV-2, the pandemic coronavirus: Molecular and structural insights.
TL;DR: In this article, a preliminary opinion about the disease, origin and life cycle of SARS-CoV-2, roles of virus proteins in pathogenesis, commonalities, and differences between different corona viruses are discussed.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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