The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease.
Thomas J Cross,Gemma R. Takahashi,Elizabeth M. Diessner,Marquise G. Crosby,Vesta Farahmand,Shannon Zhuang,Carter T. Butts,Rachel W. Martin +7 more
TL;DR: The SARS-CoV-2 main protease (Mpro) is essential to viral replication and cleaves highly specific substrate sequences, making it an obvious target for inhibitor design as discussed by the authors.
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SARS-CoV-2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID-19 pandemic.
Jorge Hallak,Thiago A Teixeira,Felipe S. Bernardes,Felipe Carneiro,Sérgio Aloísio Duarte,Juliana Risso Pariz,Sandro C. Esteves,Sandro C. Esteves,Esper G. Kallas,Paulo Hilário Nascimento Saldiva +9 more
TL;DR: The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, named coronav virus disease 19 (COVID‐19), is not the first well‐known spillover of an animal originated virus to infect humans, but one of the few to make such a fast jump in a powerful evolutionary shortcut.
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Multiscale models of Covid-19 with mutations and variants
TL;DR: In this paper , the authors focus on the multiscale modeling of the COVID-19 pandemic and present further developments of the model with the aim of showing how relaxations of the confinement rules can generate sequential waves.
Journal ArticleDOI
Viewpoint: Origin of SARS-CoV-2
Kenneth Lundstrom,Murat Seyran,Murat Seyran,Damiano Pizzol,Parise Adadi,Tarek Mohamed Abd El-Aziz,Tarek Mohamed Abd El-Aziz,Sk. Sarif Hassan,Antonio G. Soares,Ramesh Kandimalla,Murtaza M. Tambuwala,Alaa A. A. Aljabali,Gajendra Kumar Azad,Pabitra Pal Choudhury,Vladimir N. Uversky,Samendra P. Sherchan,Bruce D. Uhal,Nima Rezaei,Nima Rezaei,Adam Brufsky +19 more
TL;DR: Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor and does not appear to present a mutational "hot spot" as only the D614G mutation has been identified from clinical isolates.
Journal ArticleDOI
SARS-CoV-2 will continue to circulate in the human population: an opinion from the point of view of the virus-host relationship.
Volodymyr V. Oberemok,Kateryna V. Laikova,Kseniya A. Yurchenko,Irina I. Fomochkina,Anatolii V. Kubyshkin +4 more
TL;DR: This article will concentrate on the facts currently available about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused COVID-19 (coronavirus disease 2019) pandemic and try to predict its development and consequences based on the virus-host relationship.
References
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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