The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era.
Ángel Serrano-Aroca,Kazuo Takayama,Alberto Tuñón-Molina,Murat Seyran,Sk. Sarif Hassan,Pabitra Pal Choudhury,Vladimir N. Uversky,Kenneth Lundstrom,Parise Adadi,Giorgio Palù,Alaa A. A. Aljabali,Gaurav Chauhan,Ramesh Kandimalla,Murtaza M. Tambuwala,Amos Lal,Tarek Mohamed Abd El-Aziz,Tarek Mohamed Abd El-Aziz,Samendra P. Sherchan,Debmalya Barh,Elrashdy M. Redwan,Nicolas G. Bazan,Yogendra Kumar Mishra,Bruce D. Uhal,Adam Brufsky +23 more
TL;DR: In this article, the authors evaluated the antiviral activity and broad-spectrum antimicrobial properties of carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives.
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Herbal Immune-boosters: Substantial Warriors of Pandemic Covid-19 Battle
Kanika Khanna,Sukhmeen Kaur Kohli,Ravdeep Kaur,Abhay Bhardwaj,Vinay Bhardwaj,Puja Ohri,Anket Sharma,Ajaz Ahmad,Renu Bhardwaj,Parvaiz Ahmad +9 more
TL;DR: The present review discusses the vital concepts related to COVID-19, in terms of its origin, transmission, clinical aspects and diagnosis, and formulated the novel concept hitherto, ancient means of traditional medicines or herbal plants to beat this pandemic.
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Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin.
TL;DR: In this paper, the impact of S1/S2 cleavage on infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was studied using pseudoparticles and protease inhibitors.
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SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective.
Manuela Sironi,Seyed Ehtesham Hasnain,Benjamin M. Rosenthal,Tung Phan,Fabio Luciani,Marie-Anne Shaw,M. Anice Sallum,Marzieh Ezzaty Mirhashemi,Serge Morand,Fernando González-Candelas +9 more
TL;DR: The authors synthesize lessons from a range of scientific perspectives rooted in epidemiology, virology, genetics, ecology and evolutionary biology so as to provide perspective on how this pandemic started, how it is developing, and how best we can stop it.
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Lancet COVID-19 Commission Statement on the occasion of the 75th session of the UN General Assembly
Jeffrey D. Sachs,Salim S. Abdool Karim,Lara B. Aknin,Joseph G. Allen,Kirsten Brosbøl,Gabriela Cuevas Barron,Peter Daszak,María Fernanda Espinosa,Vitor Gaspar,Alejandro Gaviria,Andy Haines,Peter J. Hotez,Phoebe Koundouri,Felipe Larraín Bascuñán,Jong Koo Lee,Muhammad Pate,Paul Polman,Srinath Reddy,Ismail Serageldin,Raj Shah,John Thwaites,Vaira Vike-Freiberga,Chen Wang,Miriam Were,Lan Xue,Min Zhu,Chandrika Bahadur,Maria Elena Bottazzi,Yanis Ben Amor,Lauren Barredo,Ozge Karadag Caman,Guillaume Lafortune,Emma Torres,Ismini Ethridge,Juliana G.E. Bartels +34 more
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
Journal ArticleDOI
An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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