The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation.
Antonin Tidu,Aurélie Janvier,Laure Schaeffer,Piotr Sosnowski,Lauriane Kuhn,Philippe Hammann,Eric Westhof,Gilbert Eriani,Franck Martin +8 more
TL;DR: NSP1 acts as a ribosome gatekeeper, shutting down host translation and fostering SARS-CoV-2 translation in the presence of the SL1 5′UTR hairpin, which is seen as a genuine “Achilles heel” of the virus.
Journal ArticleDOI
Extensive use of face masks during COVID-19 pandemic: (micro-)plastic pollution and potential health concerns in the Arabian Peninsula.
TL;DR: Concerns relating to extensive use of face masks in this region are highlighted, particularly in the context of (micro-)plastic pollution and it is suggested that appropriate regulations on face masks waste should be devised to avoid any unwanted consequences in the near future.
Journal ArticleDOI
Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand.
Jemma L. Geoghegan,Xiaoyun Ren,Matthew Storey,James Hadfield,Lauren Jelley,Sarah Jefferies,Jill Sherwood,Shevaun Paine,Sue Huang,Jordan Douglas,Fábio K. Mendes,Andrew Sporle,Michael G Baker,David R. Murdoch,Nigel P. French,Colin R Simpson,Colin R Simpson,David Welch,Alexei J. Drummond,Edward C. Holmes,Sebastián Duchêne,Joep de Ligt +21 more
TL;DR: The generating of 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the ‘first wave’ demonstrates the utility of genomic pathogen surveillance to inform public health and disease mitigation.
Posted ContentDOI
Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2
TL;DR: The glycosylation mapping on spike protein subunits S1 and S2 expressed on human cells through high resolution mass spectrometry is reported and the quantitative N-glycosylated profile on spikeprotein is characterized and interestingly, unexpected O-glyCosylation modifications on the receptor binding domain (RBD) of spikeprotein subunit S1 are observed.
Journal ArticleDOI
Clinical characteristics and co-infections of 354 hospitalized patients with COVID-19 in Wuhan, China: a retrospective cohort study.
TL;DR: Stepwise multivariable regression analysis suggested that co-infection, lymphocyte count and levels of D-dimer were associated with severity of COVID-19, and provide crucial clues for further identification of the mechanisms, characteristics and treatments of patients with CO VID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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