The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS.
Kam Lun Hon,Karen Ka Yan Leung,Alexander K. C. Leung,Siddharth Sridhar,Suyun Qian,So Lun Lee,Andrew A. Colin +6 more
TL;DR: This overview aims to compare and contrast the similarities and differences of these three major episodes of coronavirus outbreak, and concludes that they are essentially the same viral respiratory syndromes caused by similar strains of coronvirus with different names.
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SARS-CoV-2 virulence evolution: Avirulence theory, immunity and trade-offs.
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In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh.
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The influence of ecosystems services depletion to climate change adaptation efforts in Africa.
Walter Leal Filho,Ulisses Miranda Azeiteiro,Abdul-Lateef Balogun,Andréia Faraoni Freitas Setti,Serafino Afonso Rui Mucova,Serafino Afonso Rui Mucova,Desalegn Yayeh Ayal,Edmond Totin,Adeleke Mosunmola Lydia,Felix Kanungwe Kalaba,Nicholas Oguge +10 more
TL;DR: In this article, the role of ecosystems services in climate change adaptation in Africa is reviewed and a set of case studies from a sample of African countries, which serve the purpose to demonstrate the damages incurred, and how such damages disrupt ecosystem services.
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Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients.
TL;DR: In this paper, the authors discussed the vulnerability of the nervous system based on the pattern of expression of the receptors for the SARS-CoV2 and the mechanisms of its cell invasion.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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