The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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Journal ArticleDOI
Sensitive Recovery of Complete SARS-CoV-2 Genomes from Clinical Samples by Use of Swift Biosciences' SARS-CoV-2 Multiplex Amplicon Sequencing Panel.
Amin Addetia,Michelle J. Lin,Vikas Peddu,Pavitra Roychoudhury,Pavitra Roychoudhury,Keith R. Jerome,Keith R. Jerome,Alexander L. Greninger,Alexander L. Greninger +8 more
TL;DR: Whole genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a better understanding of the virus's origin, transmission, and evolution.
Journal ArticleDOI
Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production
TL;DR: In this paper, the role of S protein glycosylation in mediating virus-receptor interactions and antibody production is summarized, as well as indications for vaccine development. But it is not shown that S protein epitopes are important in eliciting neutralizing antibodies.
Journal ArticleDOI
Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients.
Cristina Andrés,Damir Garcia-Cehic,Josep Gregori,Josep Gregori,Maria Piñana,Francisco Rodriguez-Frias,Mercedes Guerrero-Murillo,Juliana Esperalba,Ariadna Rando,Lidia Goterris,Maria Gema Codina,Susanna Quer,Mercedes Martín,Magda Campins,Ricard Ferrer,Benito Almirante,Juan Ignacio Esteban,Tomás Pumarola,Andrés Antón,Josep Quer +19 more
TL;DR: It is suggested that natural selection has favoured a “Don’t burn down the house” strategy, in which free S1 protein may compete with viral particles for the ACE2 receptor, thus reducing the severity of the infection and tissue damage without losing transmission capability.
Journal ArticleDOI
HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV.
Aleksandra Milewska,Ying Chi,Artur Szczepanski,Emilia Barreto-Duran,Agnieszka Dabrowska,Pawel Botwina,Magdalena Obłoza,Kevin Liu,Dan Liu,Xiling Guo,Yiyue Ge,Li Jingxin,Lunbiao Cui,Marek Ochman,Maciej Urlik,Sylwia Rodziewicz-Motowidło,Fengcai Zhu,Fengcai Zhu,Krzysztof Szczubiałka,Maria Nowakowska,Krzysztof Pyrc +20 more
TL;DR: The antiviral activity of an HTCC compound, previously developed by us, is described, which may be used as a potential inhibitor of currently circulating highly pathogenic coronaviruses—SARS- coV-2 and MERS-CoV.
Journal ArticleDOI
Neurological complications and infection mechanism of SARS-COV-2.
TL;DR: In this article, the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence was discussed and the experimental models were used to study SARS CoV2 neuroinvasion.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
Journal ArticleDOI
An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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