The proximal origin of SARS-CoV-2.
Kristian G. Andersen,Kristian G. Andersen,Andrew Rambaut,W. Ian Lipkin,Edward C. Holmes,Robert F. Garry +5 more
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TLDR
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed.Abstract:
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.read more
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High prevalence of SARS-CoV-2 and influenza A virus (H1N1) coinfection in dead patients in Northeastern Iran.
TL;DR: A high prevalence of coinfection with influenza A virus and the monopoly of coininfection with Human metapneumovirus in children are highlighted.
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The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2
Jonathan Pekar,Andrew C. Magee,Edyth Parker,Niema Moshiri,Katherine Izhikevich,J. L. Havens,Karthik Gangavarapu,Lorena Mariana Malpica Serrano,Alexander Crits-Christoph,Nathaniel L. Matteson,Mark Zeller,J. Levy,Jade C Wang,Scott Hughes,Jungmin Lee,Heedo Park,Man Seong Park,Katherine Zi Yan Ching,Raymond Lai,Mohd Noor Mat Isa,Yusuf Muhammad Noor,Tetyana I. Vasylyeva,Robert F. Garry,Edward C. Holmes,Andrew Rambaut,Marc A. Suchard,Kristian G. Andersen,Michael Worobey,Joel O. Wertheim +28 more
TL;DR: Analysis of the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronav virus disease 2019 (COVID-19) pandemic indicates that it is unlikely that SARS- covirus-2 circulated widely in humans prior to November 2019 and defines the narrow window between when Sars-Cov-2 first jumped into humans and when the first cases of CO VID-19 were reported.
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Integrative analyses of SARS-CoV-2 genomes from different geographical locations reveal unique features potentially consequential to host-virus interaction, pathogenesis and clues for novel therapies.
TL;DR: The analysis explores the functional impact of the virus mutations on its proteins and interaction of its genes with host antiviral mechanisms and predicted antiviral peptides which can be used in designing peptide based drugs against SARS-CoV-2.
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A systematic review on recent trends in transmission, diagnosis, prevention and imaging features of COVID-19.
S. Manigandan,S. Manigandan,Ming-Tsang Wu,Vinoth Kumar Ponnusamy,Vinay B. Raghavendra,Arivalagan Pugazhendhi,Kathirvel Brindhadevi +6 more
TL;DR: This study predicts the possible transmission of the virus through medical practices such as ophthalmology, dental, and endoscopy procedures and the developments of a potential technology for the identification of the infection, such as a drone with thermal screening without human intervention, need to be encouraged.
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Dental Care and Oral Health under the Clouds of COVID-19.
TL;DR: Biological and clinical evidence supports that oral mucosa is an initial site of entry for SARS-CoV-2 and that oral symptoms, including loss of taste/smell and dry mouth, might be early symptoms of COVID-19, presenting before fever, dry cough, fatigue, shortness breath, and other typical symptoms.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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