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Open AccessJournal ArticleDOI

Transmission Dynamics and Control of Severe Acute Respiratory Syndrome

TLDR
It is estimated that a single infectious case of SARS will infect about three secondary cases in a population that has not yet instituted control measures, and public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic.
Abstract
Severe acute respiratory syndrome (SARS) is a recently described illness of humans that has spread widely over the past 6 months. With the use of detailed epidemiologic data from Singapore and epidemic curves from other settings, we estimated the reproductive number for SARS in the absence of interventions and in the presence of control efforts. We estimate that a single infectious case of SARS will infect about three secondary cases in a population that has not yet instituted control measures. Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic.

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Posted ContentDOI

"No test is better than a bad test": Impact of diagnostic uncertainty in mass testing on the spread of Covid-19

TL;DR: A well designed active viral testing strategy combined with incremental relaxation of the lock-down measures is shown to be a potential strategy to restore some social activity whilst continuing to keep infections low in the Covid-19 epidemic.
Journal ArticleDOI

SARS epidemical forecast research in mathematical model

TL;DR: The SIJR model is adopted to analyze the important parameters of the model of SARS epidemic such as the transmission rate, basic reproductive number and as a by-product, the index of the effectiveness of control in the later period can be acquired.
Journal ArticleDOI

Early Real-time Estimation of Infectious Disease Reproduction Number

TL;DR: A novel method is presented that enables to make a reliable real-time estimate of the reproduction number at a much earlier stage compared to other available methods, and takes into account the possibility that a disease has a wide distribution of infectious period and that the degree distribution of the contact network is heterogeneous.
Journal ArticleDOI

Review of Epidemic, Containment Strategies, Clinical Management, and Economic Evaluation of COVID-19 Pandemic

TL;DR: In this article, the authors proposed a systematic framework for elucidating emerging infectious disease (EID) such as COVID-19 with a panorama viewpoint from natural infection and disease process, public health interventions (non-pharmaceutical interventions and vaccine), clinical treatments and therapies (antivirals), until global aspects of health and economic loss, and economic evaluation of interventions with emphasis on mass vaccination.
Journal ArticleDOI

Non-Pharmaceutical Interventions (NPIs) to Reduce COVID-19 Mortality

TL;DR: The most ideal and NPI's for conceivable decrease of R* through CFR for the interest of all nations are proposed and countries/regions can play it safe dependent on R* to diminish the spread of COVID-19.
References
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Book

Infectious Diseases of Humans: Dynamics and Control

TL;DR: This book discusses the biology of host-microparasite associations, dynamics of acquired immunity heterogeneity within the human community indirectly transmitted helminths, and the ecology and genetics of hosts and parasites.
Book

A first course in stochastic processes

TL;DR: In this paper, the Basic Limit Theorem of Markov Chains and its applications are discussed and examples of continuous time Markov chains are presented. But they do not cover the application of continuous-time Markov chain in matrix analysis.
Journal ArticleDOI

Seasonal variation in host susceptibility and cycles of certain infectious diseases.

TL;DR: Ample evidence indicates that photoperiod-driven physiologic changes are typical in mammalian species, including some in humans, and underlie human resistance to infectious diseases for large portions of the year and the changes can be identified and modified, the therapeutic and preventive implications may be considerable.
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