Transmission Dynamics and Control of Severe Acute Respiratory Syndrome
Marc Lipsitch,Ted Cohen,Ben S. Cooper,James M. Robins,Stefan Ma,Lyn James,Gowri Gopalakrishna,Suok Kai Chew,Chorh Chuan Tan,Matthew H. Samore,David N. Fisman,Megan Murray +11 more
TLDR
It is estimated that a single infectious case of SARS will infect about three secondary cases in a population that has not yet instituted control measures, and public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic.Abstract:
Severe acute respiratory syndrome (SARS) is a recently described illness of humans that has spread widely over the past 6 months. With the use of detailed epidemiologic data from Singapore and epidemic curves from other settings, we estimated the reproductive number for SARS in the absence of interventions and in the presence of control efforts. We estimate that a single infectious case of SARS will infect about three secondary cases in a population that has not yet instituted control measures. Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic.read more
Citations
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Proceedings ArticleDOI
Cost of fairness in disease spread control
Arun Vijayshankar,Sandip Roy +1 more
TL;DR: The performance of an optimal design in terms of the reduction in spread rate is compared with that of a fair one and an algebraic bound on the difference in performance (or cost of fairness) is obtained.
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Hospital Beds Planning and Admission Control Policies for COVID-19 Pandemic: A Hybrid Computer Simulation Approach
TL;DR: In this article, a hybrid computer simulation approach was developed to predict COVID-19 cases and a discrete-event simulation to evaluate hospital bed utilization and subsequently determine bed allocations, and two control policies, the type-dependent admission control policy and the early stepdown policy, based on patient risk profiling, were proposed to lower the overall death rate of the patient population in need of intensive care.
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Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human host.
Diego Forni,Rachele Cagliani,Federica Arrigoni,Martino Benvenuti,Alessandra Mozzi,Uberto Pozzoli,Mario Clerici,Luca De Gioia,Manuela Sironi +8 more
TL;DR: In this paper, the authors applied a population genetics-phylogenetic approach to investigate which selective events accompanied the divergence of these viruses from the animal ones and found that positive selection drove the evolution of some accessory proteins, as well as of the membrane proteins.
Posted ContentDOI
Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic
Mary E. Petrone,Rebecca Earnest,José Lourenço,Moritz U. G. Kraemer,Robert Paulino-Ramirez,Nathan D. Grubaugh,Leandro Tapia +6 more
TL;DR: This study evaluated whether climate and the spatio-temporal dynamics of past dengue outbreaks could inform when and where future emerging disease outbreaks might occur and advocated for the implementation of a sustainable and long-term surveillance system to monitor the spread of known mosquito-borne viruses and to identify emerging threats before they cause outbreaks.
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Network perspectives on infectious disease dynamics.
TL;DR: This special issue focuses specifically on pioneering network perspectives in the field of infectious disease epidemiology, which have already yielded important new understanding of the dynamics of infectious Disease outbreaks in humans and animals.
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