H
Hua Huang
Researcher at University of Pennsylvania
Publications - 15
Citations - 193
Hua Huang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 5 publications receiving 22 citations. Previous affiliations of Hua Huang include Children's Hospital of Philadelphia.
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Journal ArticleDOI
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer.
Zeyu Chen,Eri Arai,Omar Khan,Zhen Zhang,Shin Foong Ngiow,Yuan He,Hua Huang,Sasikanth Manne,Zhendong Cao,Amy E. Baxter,Zhangying Cai,Elizabeth Freilich,Mohammed Alkhatim A. Ali,Josephine R. Giles,Jennifer E. Wu,Allison R. Greenplate,Mohamed A. Hakeem,Qingzhou Chen,Makoto Kurachi,Kito Nzingha,Viktoriya Ekshyyan,Divij Mathew,Zhuoyu Wen,Nancy A. Speck,Alexis Battle,Shelley L. Berger,E. John Wherry,Junwei Shi +27 more
TL;DR: In this paper, the authors developed an in-vivo T-cell CRISPR screening platform and identified a key mechanism restraining TEFF biology through the ETS family TF, Fli1.
Journal ArticleDOI
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Josephine R. Giles,Shin Foong Ngiow,Sasikanth Manne,Amy E. Baxter,Omar Khan,Ping Wang,Ryan P. Staupe,Mohamed S. Abdel-Hakeem,Hua Huang,Divij Mathew,Mark M. Painter,Jennifer E. Wu,Yinghui Jane Huang,Rishi R. Goel,Patrick Yan,Giorgos C. Karakousis,Xiaowei Xu,Tara C. Mitchell,Alexander C. Huang,E. John Wherry +19 more
TL;DR: New subsets are uncovered, including a subpopulation of Tex cells expressing natural killer cell-associated genes that is dependent on the transcription factor Zeb2, as well as multiple distinct TCF-1+ stem/progenitor-like subsets in acute and chronic infection.
Journal ArticleDOI
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.
Josephine R. Giles,Sasikanth Manne,Elizabeth Freilich,Derek A. Oldridge,Amy E. Baxter,Sangeeth M. George,Ze-jian Chen,Hua Huang,Lakshmi Chilukuri,Mary Carberry,Lydia Giles,Nan-ping Weng,Regina M. Young,Carl H. June,Lynn M. Schuchter,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Alexander C. Huang,Junwei Shi,E. John Wherry +21 more
TL;DR: In this article , an epigenetic and transcriptional atlas of T cell differentiation from healthy humans that included exhausted CD8 T cells was generated and applied to three settings: a neoadjuvant anti-PD1 melanoma trial, a basal cell carcinoma scATAC-seq dataset, and autoimmune disease-associated SNPs-yielding insights into disease-specific biology.
Posted ContentDOI
Brain charts for the human lifespan
Richard A. I. Bethlehem,Jakob Seidlitz,Jakob Seidlitz,White,Jacob W. Vogel,Kevin M. Anderson,Adamson C,Sophie Adler,George S. Alexopoulos,Evdokia Anagnostou,Evdokia Anagnostou,Areces-Gonzalez A,Areces-Gonzalez A,Duncan E. Astle,Bonnie Auyeung,Bonnie Auyeung,Ayub M,Gareth Ball,Simon Baron-Cohen,Richard Beare,Saashi A Bedford,Benegal,Frauke Beyer,Bin Bae J,John Blangero,Blesa Cabez M,James P. Boardman,Matthew Borzage,Jorge Bosch-Bayard,Jorge Bosch-Bayard,Niall J Bourke,Calhoun Vd,M. Mallar Chakravarty,M. Mallar Chakravarty,Chixiang Chen,Chertavian C,Gaël Chételat,Yap Seng Chong,Yap Seng Chong,James H. Cole,Aiden Corvin,Eric Courchesne,Fabrice Crivello,Vanessa Cropley,Jennifer Crosbie,Nicolas Crossley,Nicolas Crossley,Delarue M,Sylvane Desrivières,Gabriel A. Devenyi,Gabriel A. Devenyi,Di Biase Ma,Di Biase Ma,Raymond J. Dolan,Kirsten A. Donald,Gary Donohoe,Katharine Dunlop,Alexander D. Edwards,Alexander D. Edwards,Jed T. Elison,Cameron T. Ellis,Jeremy A. Elman,Lisa T. Eyler,Lisa T. Eyler,Damien A. Fair,Paul C. Fletcher,Peter Fonagy,Carol E. Franz,Lídice Galán-García,Ali Gholipour,Jay N. Giedd,John H. Gilmore,David C. Glahn,David C. Glahn,Ian M. Goodyer,Patricia Ellen Grant,Nynke A. Groenewold,Faith M. Gunning,R.E. Gur,R.E. Gur,R.C. Gur,R.C. Gur,Hammill Cf,Oskar Hansson,Trey Hedden,Trey Hedden,A. Heinz,Richard N. Henson,Richard N. Henson,Katja Heuer,Katja Heuer,Jacqueline Hoare,Bharath Holla,Avram J. Holmes,Rosemary Holt,Hua Huang,Hua Huang,Kiho Im,Jonathan C Ipser,Clifford R. Jack,Andrea Parolin Jackowski,Andrea Parolin Jackowski,Tianye Jia,Tianye Jia,Keith A. Johnson,David T.W. Jones,Peter B. Jones,René S. Kahn,Hasse Karlsson,Linnea Karlsson,Ryuta Kawashima,Elizabeth Kelley,Silke Kern,Kim K,Manfred G. Kitzbichler,William S. Kremen,Francois Lalonde,Brigitte Landeau,Sang Jae Lee,Jason P. Lerch,Jason P. Lerch,John D. Lewis,Jianfu Li,Wei Liao,Deirel Paz Linares,Conor Liston,Michael V. Lombardo,Michael V. Lombardo,Jinglei Lv,Jinglei Lv,Charles J. Lynch,Travis T. Mallard,Machteld Marcelis,Ross D. Markello,Bernard Mazoyer,Phillip McGuire,Michael J. Meaney,Andrea Mechelli,Nenad Medic,Bratislav Misic,Sarah E. Morgan,Sarah E. Morgan,Mothersill D,Mothersill D,Mothersill D,Joel T. Nigg,Ong Mq,Cynthia M. Ortinau,Rik Ossenkoppele,Rik Ossenkoppele,Minhui Ouyang,Lena Palaniyappan,Paly L,Pedro Mario Pan,C Pantelis,C Pantelis,Park Mtm,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Zdenka Pausova,Pichet Binette A,Pichet Binette A,Karen Pierce,Xinlei Qian,Anqi Qiu,Jiang Qiu,Armin Raznahan,Timothy Rittman,Caitlin K. Rollins,Caitlin K. Rollins,Romero-Garcia R,Romero-Garcia R,Lisa Ronan,Rosenberg,David H. Rowitch,Giovanni Abrahão Salum,Theodore D. Satterthwaite,Herma Lina Schaare,Russell Schachar,Michael Schöll,Michael Schöll,Aaron P. Schultz,Gunter Schumann,Gunter Schumann,David J. Sharp,Russel T. Shinohara,Ingmar Skoog,Christopher D. Smyser,Reisa A. Sperling,Reisa A. Sperling,Dan J. Stein,Stolicyn A,John Suckling,Gareth J. Sullivan,Taki Y,Thyreau B,Roberto Toro,Roberto Toro,Kamen A. Tsvetanov,Nicholas B. Turk-Browne,Tuulari Jj,Christophe Tzourio,Etienne Vachon-Presseau,Mitchell Valdés-Sosa,Pedro A. Valdes-Sosa,Sofie L. Valk,van Amelsvoort T,Simon N. Vandekar,Simon N. Vandekar,Lana Vasung,Petra E. Vértes,Petra E. Vértes,Lindsay W. Victoria,Sylvia Villeneuve,Sylvia Villeneuve,Sylvia Villeneuve,Arno Villringer,Arno Villringer,Konrad Wagstyl,Wang Ys,Simon K. Warfield,Warrier,Warrier,Warrier,Eric Westman,Margaret L. Westwater,Heather C. Whalley,A. V. Witte,A. V. Witte,Yang N,Yeo Bt,Yun Hj,Andrew Zalesky,Heather J. Zar,Anna Zettergren,Juan Zhou,Hisham Ziauddeen,André Zugman,Zuo Xn,E.T. Bullmore,Aaron Alexander-Bloch,Aaron Alexander-Bloch +242 more
TL;DR: In this paper, the authors built an interactive resource (www.brainchart.io) to benchmark individual differences in brain morphology, measured from any current or future magnetic resonance imaging (MRI) study, against normative age-related trends.
Journal ArticleDOI
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
Zhendong Cao,Krista A. Budinich,Hua Huang,Diqiu Ren,Bin Lu,Zhen Zhang,Qingzhou Chen,Yeqiao Zhou,Yu-Han Huang,Fatemeh Alikarami,Molly C. Kingsley,Alexandra Lenard,Aoi Wakabayashi,Aoi Wakabayashi,Eugene Khandros,Eugene Khandros,Will Bailis,Jun Qi,Martin Carroll,Gerd A. Blobel,Gerd A. Blobel,Robert B. Faryabi,Kathrin M. Bernt,Kathrin M. Bernt,Shelley L. Berger,Junwei Shi +25 more
TL;DR: In this article, the authors discover and characterize the mechanism by which the chromatin "reader" ZMYND8 directly activates IRF8 in parallel with the MYC proto-oncogene through their lineage-specific enhancers.