M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
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Journal ArticleDOI
FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING Activation
Journal ArticleDOI
Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Shabnam Shalapour,Xue Jia Lin,Xue Jia Lin,Ingmar N. Bastian,John G. Brain,Alastair D. Burt,Alexander A. Aksenov,Alison Vrbanac,Wei-Hua Li,Andres Perkins,Takaji Matsutani,Zhenyu Zhong,Debanjan Dhar,Jose A. Navas-Molina,Jun Xu,Rohit Loomba,Michael Downes,Ruth T. Yu,Ronald M. Evans,Pieter C. Dorrestein,Pieter C. Dorrestein,Rob Knight,Christopher Benner,Quentin M. Anstee,Michael Karin +24 more
TL;DR: In this Article, the sentence: “After 7 months of HFD, MUP-uPA mice developed HCC15, which contained numerous (usually 50–100 per tumour) non-recurrent coding mutations in pathways that are mutated in human HCC (Fig. 2d and Extended Data Fig. 6a).”, should have read: ”After 7months of H FD, HCC 15, which contain numerous ( usually 50– 100 per tumours)
Patent
Methods and compositions for reducing microbial induced apoptosis
Li-Chung Hsu,Michael Karin +1 more
TL;DR: In this paper, the authors proposed a method to reduce the activity of protein Kinase R (PKR) in the presence of microbial infection, and the screening of agents that reduce apoptosis.
Journal Article
NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals
Zhenyu Zhong,Atsushi Umemura,Elsa Sanchez-Lopez,Shuang Liang,Shabnam Shalapour,Jerry Wong,Feng He,Daniela Boassa,Guy Perkins,Syed Raza Ali,Matthew G McGeough,Mark H. Ellisman,Ekihiro Seki,Åsa B. Gustafsson,Hal M. Hoffman,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +17 more
TL;DR: The “NF-κB-p62-mitophagy” pathway is a macrophage-intrinsic regulatory loop through which NF-κBs restrains its own inflammation-promoting activity and orchestrates a self-limiting host response that maintains homeostasis and favors tissue repair.
Journal ArticleDOI
Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.
Lixiang Gu,Yahui Zhu,Maiya Lee,Albert Nguyen,Nicolas T Ryujin,Shusil K. Pandit,Shadi M. Chamseddine,Lianchun Xiao,Yehia I. Mohamed,Ahmed Kaseb,Michael Karin,Shabnam Shalapour +11 more
TL;DR: In this paper , the angiotensin II receptor inhibitor losartan, a commonly prescribed and safe antihypertensive drug, reduced liver and peritumoral fibrosis and substantially enhanced anti-PD-1-induced tumor regression.