M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer
TL;DR: This multifunctional protein is a key regulator of keratinocyte and epidermal differentiation and a critical suppressor of skin cancer.
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Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.
Arthur S. Alberts,Tiliang Deng,Anning Lin,J L Meinkoth,Axel Schönthal,Marc C. Mumby,Michael Karin,James R. Feramisco +7 more
TL;DR: Results suggest a specific role for PP2A in signal transduction pathways that regulate AP-1 activity and c-Jun expression in cell lines containing stably transfected lacZ marker genes under the control of an enhancer recognized byAP-1.
Journal ArticleDOI
Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner
Frank Mercurio,Michael Karin +1 more
TL;DR: The identification and characterization of activator protein‐3 (AP‐3), which recognizes the core element of the SV40 enhancer, was purified to near homogeneity and identified as a 48K polypeptide, which is an efficient transcriptional activator in vitro.
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Inflammation and liver tumorigenesis
Beicheng Sun,Michael Karin +1 more
TL;DR: This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells.