M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal Article
Inhibitor of Nuclear Factor κB Kinase Deficiency Enhances Oxidative Stress and Prolongs c-Jun NH2-Terminal Kinase Activation Induced by Arsenic
TL;DR: Increased CYP1B1 expression is central to and seems to be responsible for sensitizing Ikkbeta(-/-) cells to stress-induced JNK activation, which was largely associated with an oxidative stress response.
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Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis
Yolanda Bayón,Maria A. Ortiz,Francisco J. López-Hernández,Feng Gao,Michael Karin,Magnus Pfahl,F. Javier Piedrafita +6 more
TL;DR: It is found that retinoid antagonist MX781 inhibited the activation of NF-κB-dependent transcriptional activity in different tumor cell lines and induction of apoptosis by the Retinoid-related molecules that inhibited IKK was dependent on caspase activity but independent of the retinoids receptors.
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Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity
Yoko Takanami-Ohnishi,Yoko Takanami-Ohnishi,Shinya Amano,Sadao Kimura,Sachie Asada,Sachie Asada,Atsushi Utani,Masumi Maruyama,Hiroyuki Osada,Hajime Tsunoda,Yoko Irukayama-Tomobe,Katsutoshi Goto,Michael Karin,Tatsuhiko Sudo,Yoshitoshi Kasuya +14 more
TL;DR: It is suggested that p38 plays a key role in CHS and is an important target for the treatment of CHS.
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Induction of Metallothionein mRNA in HeLa Cells by Dexamethasone and by Heavy Metals
TL;DR: Increased synthesis and accumulation of metallothionein in response to either metal or glucocorticoid exposure is regulated by the level of translatable metallothsionein mRNA in HeLa cells.
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Choline kinase inhibition in rheumatoid arthritis
Monica Guma,Elsa Sanchez-Lopez,Alessia Lodi,Ricard Garcia-Carbonell,Stefano Tiziani,Michael Karin,Juan Carlos Lacal,Gary S. Firestein +7 more
TL;DR: Data suggest that ChoKα inhibition could be an effective strategy in inflammatory arthritis and suggests that targeting the metabolome can be a new treatment strategy in non-cancer conditions.