M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.
TL;DR: CUP2, which is on chromosome VII, codes for or controls the synthesis or activity of a protein which binds the upstream control region of the CUP1 gene on chromosome VIII, establishing CUP2 as a regulatory gene for expression of theCUP1 metallothionein gene product.
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
Debanjan Dhar,Laura Antonucci,Hayato Nakagawa,Ju Youn Kim,Elisabeth Glitzner,Stefano Caruso,Shabnam Shalapour,Ling Yang,Mark A. Valasek,Sooyeon Lee,Kerstin Minnich,Ekihiro Seki,Jan Tuckermann,Maria Sibilia,Jessica Zucman-Rossi,Michael Karin +15 more
TL;DR: CD44, a hyaluronic acid receptor whose expression is rapidly induced in carcinogen-exposed hepatocytes in a STAT3-dependent manner, allows DNA-damaged hepatocytes to escape p53-induced death and senescence and respond to proliferative signals that promote fixation of mutations and their transmission to daughter cells that go on to become HCC progenitors.
Journal ArticleDOI
Kinase regulation in inflammatory response
TL;DR: The transcription factor NF-κB is a pivotal regulator of innate immune responses, whose activity is rapidly induced by proinflammatory stimuli, most notably the tumour-necrosis factor TNFα and interleukin-1, viruses, and components of bacterial cell walls.
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The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.
Rhoda M. Alani,Powel H. Brown,Bernard Binétruy,Hirotoshi Dosaka,Richard K. Rosenberg,Peter Angel,Michael Karin,Michael J. Birrer +7 more
TL;DR: The studies indicate that there is a direct correlation between the ability of the c-Jun protein to activate transcription and cotransform rat embryo cells and the hypothesis that c- Jun transforms cells by stimulating the expression of transformation-mediating genes.
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An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.
Peng Zhao,Xiaoli Sun,Cynthia Chaggan,Zhongji Liao,Kai in Wong,Feng He,S Singh,Rohit Loomba,Michael Karin,Joseph L. Witztum,Alan R. Saltiel +10 more
TL;DR: The AMPK–caspase-6 axis regulates liver damage in NASH, implicating AMPK and caspases-6 as therapeutic targets for the treatment of NASH.